摘要
[目的]探讨戊酸雌二醇片用于非绝经期妇女子宫全切术后激素补充治疗的临床疗效.[方法]选取因患妇科良性疾病在绝经前行子宫全切术（保留卵巢）的患者276例（A组）,术后予戊酸雌二醇片进行激素补充治疗6个月;245例（B组）患者术后未接受任何激素补充治疗,测定两组患者治疗前后卵泡刺激素（FSH）、黄体生成素（LH）、雌二醇（E2）水平,并比较两组患者围绝经期症状.[结果]A组术前、术后3个月及术后6个月血清FSH、LH、E2水平比较无统计学意义（P＞0.05）,B组术前、术后3个月及术后6个月血清FSH、LH、E2水平比较有统计学意义（P＜0.05）.A组患者术后6个月内围绝经期症状、性生活变化、阴道黏膜改变发生率（3.62％、3.98％、4.71％）均低于B组患者（40％、39.18％、35.51％）,其差异有统计学意义（P＜0.05）.[结论]戊酸雌二醇片用于子宫全切术后患者可有效预防及改善围绝经期症状,有利患者术后恢复.
[Objective]To explore the efficacy of estradiol valerate tablets as hormone replacement therapy in non-menopausal women after total hysterectomy.[Methods] Totally 276 premenopausal women with benign gynecological disease undergoing total hysterectomy（reserving ovary） before menopause（group A） were selected and given estradiol valerate tablets as hormone replacement therapy for 6 months after operation.Other 245 patients （group B） did not receive any hormone replacement therapy after operation.The levels of follicle-stimulating hormone（FSH）,luteinizing hormone（LH） and estradiol（E2） of two groups before and after treatment were measured.Peri-menopausal symptoms were compared between two groups.[Results] In the treatment group,there was no significant difference in serum levels of FSH,LH and E2 among before,3 months and 6 months after operation （P ＞0.05）.In the control group,there were significant differences in serum levels of FSH,LH and E2 among before,3 months and 6 months after operation（P ＜0.05）.The menopausal symptoms,sexual life changes and the incidence of vaginal mucosa lesion in group A at 6 months after operation（3.62％,3.98％ and 5.78％,respectively） were lower than those in the control group（40％,39.18％ and 31.52％,respectively）,and there was significant difference（P ＜0.05）.[Conclusion] Estradiol valerate tablets can effectively prevent and improve perimenopausal symptoms of patients after total hysterectomy,and is helpful for postoperative recovery of patients.
出处
《医学临床研究》
CAS
2014年第9期1718-1720,共3页
Journal of Clinical Research
