小剂量阿司匹林对子痫前期早期干预和预防作用

The early intervention and preventive value of low- dose aspirin in preeclampsia

子痫前期是母儿围产期死亡及医源性早产的重要原因,近年来越来越多研究表明妊娠期应用小剂量阿司匹林可改善子痫前期发病过程中前列环素(PGI2)/血栓素A2(TXA2)比例失衡所致的血液高凝状态,从而预防子痫前期的发生。建议有高危因素的孕妇,在妊娠早期结束后尽快开始口服小剂量阿司匹林,在有效预防子痫前期发病的同时并不增加胎儿及产妇的出血风险,从而获得良好的母儿结局。

Preeclampsia is a common obstetric disorder with high perinatal mortality and,iatrogenic preterm birth. There is extensive evidence from randomized studies that modulating the impaired PGI2/TXA2 ratio in pathogenesis of preeclampsia by prophylactic administration of low-dose aspirin appears to be asso- ciated with a reduction in the prevalence of pre- eclampsia. It is recommended to initiate administration of daily low-dose aspirin beginning in the late first trimester for women at risk to prevent preeclampsia while not inducing maternal and fetal hemorrhage.