硫酸镁联合拉贝洛尔治疗78例孕妇妊娠期高血压的随机对照研究

Randomized Controlled Study of Magnesium Sulfate Combined with Labetalol in the Treatment of Gestational Hypertension in Pregnant Women: Analysis of 78 Cases

目的:研究硫酸镁联合拉贝洛尔治疗妊娠期高血压对孕妇血压、新生儿Apgar评分的影响,并探讨其作用机制。方法:选取2012年3月至2013年12月在我院妇产科住院的156例妊娠期高血压孕妇,采用随机数字表法分为试验组和对照组各78例。试验组给予硫酸镁联合拉贝洛尔治疗,对照组仅给予同等剂量的硫酸镁治疗。用药结束后比较两组孕妇血压的下降情况,并比较两组新生儿Apgar评分情况。结果:治疗前两组孕妇收缩压和舒张压比较差异均无统计学意义(P均>0.05);治疗后试验组孕妇的收缩压和舒张压分别下降了19.7%和18.4%(P均<0.01),而对照组分别下降了10.0%和12.3%(P均<0.01),且试验组孕妇的收缩压和舒张压比对照组下降更明显(P均<0.01)。试验组新生儿Apgar评分≥7分者67例(85.90%),平均评分(9.42±0.57)分;对照组新生儿评分≥7分者54例(69.23%),平均评分(8.36±0.49)分,两组比较差异均有统计学意义(P均<0.05)。结论:硫酸镁联合拉贝洛尔治疗妊娠期高血压,能有效降低孕妇血压(包括收缩压和舒张压),有利于提高妊娠期高血压孕妇的新生儿的Apgar评分,其远期安全性有待进一步多中心大样本的研究及对不良反应的长期监测。

Objective： To study the therapeutic effect of magnesium sulfate combined with labetalol in treating gestational hypertension, effects on blood pressure in pregnant women, newborns Apgar score, and explore the mechanism of two drugs. Methods： One hundred and fifty-six cases of gestatlonal hypertension pregnant women were selected in our hospital from March 2012 to December 2013, these cases were randomly divided into two groups. The treatment group of 78 cases was given magnesium sulfate combined with labetalol, the control group of 78 cases was given the same dose of magnesium sulfate. At the end of treatment, the blood pressure was compared in pregnant women and Apgar score was compared in newborns. Results： Before treatment, the systolic and diastolic blood pressure in two groups of patients were not significantly different （ P〉0.05 ）, after treatment, the systolic and diastolic blood pressure decreased 19.7% and 18. 4% in the treatment group, decreased 10. 0% and 12.3% in the control group, there were significant differences between the two groups （P〈0.01）, and the blood pressure in treatment group decreased more significantly than that of the control group （P〈0.01）. In treatment group there were 67 cases whose neonatal Apgar score ≥ 7 points （85.90%）, the average score was （9.42 ±0. 57 ） points, 54 cases （69. 23 % ） in the control group and the average score was （8.36±0.49） points, there were significant difference between the two groups （P〈0.05）. Conclusion： Magnesium sulfate combined with labetalol in the treatment of gestational hypertension has good clinical curative effect and few adverse reactions, can effectively reduce maternal blood pressure （including systolic and diastolic）, will help improve the neonatal Apgar score, its long-term safety needs to be further research,and need a long-term monitoring of adverse reactions.