湿法快速消解-石墨炉原子吸收光谱法测定藏力康胶囊中镉的含量

Determination of Cadmium in Zanglikang Capsules by Wet Digestion Method and Graphite Furnace Atomic Absorption Spectrometric Method

目的建立石墨炉原子吸收光谱法测定藏力康胶囊中镉含量的方法。方法采用湿法快速消解法消解样品,用石墨炉原子吸收光谱法测定镉的含量。结果镉的线性范围为0～10 ng·mL^-1;标准曲线方程式为非线性通过零点,r=0.9994;平均回收率为105.1%,RSD=2.1%（n=6）,仪器检出限为0.4 pg。3批藏力康胶囊镉的含量均低于中国药典和美国FDA对药品与功能性食品镉限量标准的要求（Cd≤0.3μg·g^-1）。结论该方法准确、可靠,适用于藏力康胶囊等保健食品中镉的含量测定。

Objective To develop a graphite furnace atomic absorption spectrometric （GFAAS） method for the determination of cadmium （Cd） in Zanglikang Capsules. Methods The wet digestion was used for the treatment of samples. The content of cadmium was determined by GFAAS. Results The linear range of Zanglikang Capsules was 0-10 ng·mL^-1. The standard curve equation was nonlinear with zero, the correlation coefficient was 0.9994. The average recovery was 105.1%, RSD=2.1%（n=6）. The detection limit was 0.4 pg. The Cd content of the three batches of Zanglikang Capsules was no higher than 0.3 μg·g^-1, the limit of Cd required by Chinese Pharmacopeia and FDA of USA. Conclusion The established method is accurate, reliable, and is suitable for the determination of cadmium in Zanglikang Capsules.