葡萄糖苷酶抑制剂类药物临床研究和应用

Clinical research and application of carbon glycosidase inhibitors

α-葡萄糖苷酶抑制剂(AGI)通过延缓碳水化合物吸收而降低餐后高血糖,是2型糖尿病治疗中应用广泛的一线治疗药物。近年来的循证研究显示,阿卡波糖还可以通过调节肠道菌群及胃肠激素,改善2型糖尿病患者的血糖以及其他代谢性指标,这些新的作用机制,将为AGI类药物带来更为广阔的临床应用前景。

Glucosidase inhibitors （AGI） reduce postprandial hyperglycemia by delaying carbohydrate absorption, first-line therapy is applied widely in type 2 diabetes mellitus patients. Study on evidence-based in recent years show, acarbose can also through the regulation of intestinal flora and gastrointestinal hormones in patients with type 2 diabetes, improve blood glucose and other metabolic indices ,these new mechanisms of action for AGI drugs ,will bring more broad prospects for clin- ical application.