乌梅汤合中药灌肠治疗寒热错杂型溃疡性结肠炎30例观察

Observation on 30 cases with ulcerative colitis mixed the heat and cold treated by Wumei decoction combined with Chinese medicine enema

目的:观察中药内服配合灌肠治疗慢性溃疡性结肠炎(UC)寒热错杂证的临床疗效。方法:60例UC患者随机分为治疗组30例,给予乌梅汤内服并配合灌肠治疗;对照组30例,给予口服美沙拉嗪1g/d,4次/d。连续治疗8周后评价临床疗效、中医证候疗效、主要症状评分及肠黏膜评分,观察不良反应。结果:治疗组临床疗效、证候疗效总有效率均为90.0%,对照组均为73.3%,两组比较差异均有统计学意义(P<0.05)。两组患者治疗后腹痛、腹泻、脓血便症状积分均明显降低(P<0.05),并且治疗组治疗后腹痛、腹泻积分明显低于对照组(P<0.05);治疗后治疗组肠黏膜积分改善优于对照组(P<0.05)。结论:乌梅汤内服配合灌肠治疗溃疡性结肠炎疗效肯定,能明显改善临床症状,且无明显不良反应。

Objective： To observe the clinical curative effect of Traditional Chinese Medicine combined with enema in the treatmentof chronic ulcerative colitis （UC） mixed with heat and cold. Methods： 60 patients with UC were randomly divided into the treatment groupwith 30 cases treated with Wumei decoction combined with Chinese medicine enema, the control group with 30 cases treated with oralmesalazine 1 g each time, 4 times a day. After treatment of 8 weeks, the clinical curative effect, Chinese medicine syndrome curative effect,main symptom scores and intestinal mucosa score were evaluated, and adverse reactions were observed. Results： The clinical curativeeffect and the total effective rate was 90.0%, while that of the control group was 73.3%, with statistical significance （P〈 0.05）. Aftertreatment, the abdominal pain, diarrhea, and purulent blood symptom scores were significantly lower （P〈 0.05）, and the abdominal pain,diarrhea scores of the treatment group were significantly lower than those of the control group （P〈 0.05）; after treatment, the intestinalmucosa integral improvement was better than that of the control group （P〈 0.05）. Conclusion： Wumei decoction combined with Chinesemedicine enema has curative effect on ulcerative colitis which, can significantly improve the clinical symptoms, with no obvious adversereactions.