九味霸咳汤治疗顽固性咳嗽的临床研究

Clinical Study on Treatment of Intractable Cough with Jiuwei Ba'ke Decoction

目的:探讨九味霸咳汤干预ACEI类药物导致顽固性咳嗽的临床效果。方法:选择66例ACEI类药物导致顽固性咳嗽患者,随机分为九味霸咳汤治疗组(简称观察组)以及清燥救肺汤治疗组(简称对照组),治疗后观察两组患者咳嗽、咽部症状消失时间以及疗效,采用SF-36评价两组患者治疗后6个月的生活质量。结果:与对照组比较,观察组患者的咳嗽消失时间与咽部症状消失时间均降低明显,差异具有统计学意义(P<0.05)。观察组有效率96.97%优于对照组有效率81.82%,差异具有统计学意义(P<0.05)。与对照组比较,观察组患者各项生活质量指标均改变不明显,差异无统计学意义(P>0.05)。结论:九味霸咳汤可明显改善ACEI类药物导致顽固性咳嗽患者的临床症状,提高疗效。

Objective： To investigate the clinical effect of Jiuwei Ba’ke Decoction on intractable cough lead by ACEI drugs. Method：66 cases of patients with intractable cough lead by were randomly divided Jiuwei Ba’ke Decoction group （observation group） andDryness-clearing and Lung-rescuing Decoction group （control group）. The cough,throat symptom disappearing time and curative effect ofthe two groups were observed. The life quality of patients in the two groups six months after the treatment was evaluated by SF-36. Results：Compared with the control group, the cough and throat symptoms disappearing time of the observation group were significantly reduced,and the difference was statistically significant （P 〈0.05）. The effective rate of observation group was 96.97% which is higher than that（81.82%） of control group. The difference was statistically significant （P 〈0.05）. Compared with the control group, the changes of lifequality indicators of observation group are not obvious, and the difference was not statistically significant （P〉 0.05）. Conclusion： JiuweiBa’ke Decoction can significantly improve the clinical symptoms of patients with intractable cough lead by ACEI drugs and improve thecurative efficacy.