颅脑损伤病人血管紧张素与低钠血症的相关性研究

THE CORRELATION STUDY BETWEEN ANGIOTENSIN AND HYPONATREMIA IN PATIENTS WITH CRANIOCEREBRAL INJURY

目的探讨颅脑损伤病人发生低钠血症的病因及防治措施。方法随机测定并统计分析60例单纯性颅脑损伤病人伤后1、7、14d的血浆抗利尿激素(ADH)、血管紧张素Ⅱ(AngⅡ),及128例颅脑损伤并发低钠血症病人血浆中ADH、AngⅡ及24h尿钠。结果颅脑损伤后1、7、14d三组ADH、AngⅡ水平均明显高于对照组(P<0.01);颅脑损伤发生低钠血症的病人中,停用脱水药出入量平衡组血浆中ADH、AngⅡ与对照组比较差异有统计学意义(P<0.01),与血浆钠浓度呈负相关;停用脱水药、出量大于入量组病人血浆中ADH、AngⅡ明显降低,差异有统计学意义(P<0.05),与血浆钠浓度呈正相关。结论 AngⅡ在低钠血症的发生中起到了重要的作用。

Objective To explore the causes and preventive measures of hyponatremia of patients with ponatremia were also measured .Results The ADH ,and angiotensin Ⅱ levels of the three groups injured on 1st day ,7thday and 14thday were significantly higher than those in the control group （ P〈0 .01） .Among the craniocerebral injury patients with hyponatremia ,the difference of ADH and AngⅡ in plasma between the group of input equaling output after dehydrant being stopped and the control group was statistically significant（ P 〈0 .01） ,which was negatively correlated with serum sodium concentration .The ADH and Angiotensin Ⅱ level of the group whose output volume was more than the input volume decreased signifi-cantly compared with the control group ,which was statistically significant and was positively correlated with serum sodium concentration .Conclusion Angiotensin Ⅱ plays an important role in the occurrence of hyponatremia .