血清VEGF水平对创伤组织修复的影响

THE EFFECT OF SERUM VEGF LEVEL ON WOUND TISSUE REPAIR

目的探讨创伤患者血清VEGF水平与创伤组织愈合的关系。方法采用酶联夹心法测定62例皮肤软组织创伤患者、33例创伤性骨折患者和25例外科手术患者血清VEGF的水平,分析其与创伤组织愈合时间的关系。结果皮肤软组织创伤患者、普外科手术患者和创伤性骨折患者三组血清VEGF的水平之间在外伤后1周时差异不明显,2周时前两组骨折组患者血清VEGF水平差异明显有统计学意义(P<0.01);三组患者血清VEGF水平与创伤组织临床愈合进程相一致。结论 VEGF是组织创伤愈合的重要作用因子,创伤患者血清VEGF水平反映了创伤组织愈合的进程。

Objective To investigate the relationship between the level of serum VEGF in patients with trauma and wound healing .Methods The serum VEGF levels of 62 cases of skin soft tissue trauma ,33 ca-ses of traumatic fracture and 25 cases of surgical operation were detected with enzyme linked sandwich method ,and the relationship between the VEGF levels and the healing time of wound tissues was anlyzed . Results The serum VEGF levels of patients with skin soft tissue trauma ,patients receiving general surgery and patients with traumatic fracture showed no obvious difference one week after trauma ,but the serum VEGF levels of patients with skin soft tissue trauma ,patients receiving general surgery showed significant difference two weeks after fracture（ P 〈0 .01） .The serum VEGF level and the healing process of clinical trauma tissue were consistent . Conclusion VEGF is an important factor for wound healing ,and serum VEGF levels in patients with trauma can reflect the wound healing process .