右美托咪定在腹腔镜手术全麻拔管期应用的临床效果分析

Clinical effects of application of dexmedetomidine in tube drawing period of general anesthesia for 68 patients receiving laparoscopic surgery

目的：探讨和分析在腹腔镜术后全麻拔管期应用右美托咪定的临床疗效及作用。方法选取2012年12月-2013年12月在我院行腹腔镜手术治疗的患者68例为研究对象，随机分成对照组和研究组，于术毕带导管转入PACU（麻醉后监测治疗室）后，分别采用不同麻醉药物进行处理，其中对照组采用靶控输注丙泊酚处理，研究组给予右美托咪定。结果四组患者MAP、BIS在T2、T3、T4、T5时与T1时对比，差异均有统计学意义（P〈0.05）；A2组与A3组患者VAS评分及不良反应情况分别与对照组比较具有显著性差异（P〈0.05）。结论腹腔镜术后全麻拔管期应用右美托咪定进行镇痛和镇静，有助于维持血流动力学的稳定，减轻术后疼痛，降低术后并发症发生率。

Objective To explore and analyze the clinical efficacy and effects of the application of dexmedetomidine in the tube drawing period of general anesthesia for the patients receiving laparoscopic surgery. Methods Sixty-eight pa-tients who received laparoscopic surgery in our hospital from December 2012 to December 2013 were selected as the study subjects and randomly divided into the control group and the study group. By the end of surgery, the patients were transferred to the post-anesthesia care unit （PACU） with catheter and different anesthetic drugs were used. The control group received target controlled infusion of propofol and the study group received dexmedetomidine. Results The four groups of patients were different in MAP and BIS at T2, T3, T4 and T5, with statistically significant differ-ences （P〈0.05）. Regarding to VAS scores and adverse reactions, group A2 and group A3 were different from the control group respectively, with significant differences （P〈0.05）. Conclusion The application of dexmedetomidine in the tube drawing period of general anesthesia after laparoscopic surgery for the purpose of analgesia and sedation is conducive to maintaining hemodynamic stability, relieving postoperative pain and reducing the incidence of postoperative complica-tions.