阿奇霉素序贯疗法治疗小儿支原体肺炎的疗效及安全性分析

Analysis of the efficacy and safety of Azithromycin sequential therapy in treatment with mycoplasma pneumonia

目的：评价阿奇霉素序贯疗法用于小儿支原体肺炎治疗的疗效及安全性。方法选取2012年4月-2013年6月间于我院呼吸科就诊治疗的肺炎支原体感染患儿134例，按照治疗方式差异分为观察组和对照组，分别采用阿奇霉素序贯疗法及静脉滴注红霉素进行治疗，对比分析两组患儿的临床效果及不良反应发生情况。结果经14 d治疗后，观察组的治疗有效率为95.71%，较对照组（79.69%）显著升高（P〈0.05）；观察组患儿咳嗽、发热、肺部湿啰音消失时间及住院时间均显著缩短（P〈0.05）；同时，观察组的关节疼痛、皮疹、胃肠道反应、血清谷丙转氨酶升高的发生率均显著低于对照组（P〈0.05）。结论采用阿奇霉素序贯疗法治疗小儿支原体肺炎，具有良好的临床疗效，显著缩短患儿的症状消失时间及住院时间，且毒副作用小，值得在临床广泛使用。

Objective To evaluate the efficacy and safety of azithromycin sequential therapy in treatment with my-coplasma pneumonia. Methods A total of 134 cases with mycoplasma pneumonia were selected in respiratory depart-ment of our hospital during April 2012 to June 2013, and then divided into observation group and control group ac-cording to the different treatment, which received azithromycin sequential therapy and erythromycin intravenous infu-sion respectively. The clinical effects and the incidence of adverse reactions were comparatively analyzed. Results 14 d after treatment,the treatment efficiency of observation group reached 95.71%,which was significantly higher than that in control （79.69%）（P〈0.05）.The fading time of coughing,the fading time of crackles and rale and the time of fever descending to normal were significantly shorter than that in control （P〈0.05）. Meanwhile,the adverse reaction rate of the observation group, include joint pain, rash, gastrointestinal reactions, elevated serum alanine aminotransferase,were significantly lower than that in the control group （P〈0.05）. Conclusion Azithromycin sequential therapy have a good clinical efficacy in treatment with mycoplasma pneumonia, shorten the symptoms disappearance time and hospi-talization time and reduce toxicity,which is widely used in clinical practice.