丝状真菌生物膜的生物特性及其在眼科中的研究进展

Characteristics of filamentous fungal biofilms and their roles in ophthalmology

丝状真菌生物膜是外基质包裹菌丝和孢子形成的致密均一网状结构.其形成过程受复杂的分子机制调控.形成的丝状真菌生物膜能抵抗抗菌药物、逃避宿主免疫反应,严重威胁机体.丝状真菌生物膜在眼部感染中起重要作用.它主要通过两种方式参与眼部感染：一种是在眼部的非生物材料表面形成真菌生物膜,侵袭角膜;一种是在眼部直接形成真菌生物膜.本文综述了丝状真菌生物膜的生物学特点及其在眼科感染中的重要性.

A filamentous fungal biofilm is a collection of hyphae and spores encased in a matrix,which has distinct developmental phases governed by complex molecular events.Resistance to antifungal drugs and components of the innate immune system remain the greatest threats to patients with filamentous fungal biofilms.There is increasing evidence that filamentous fungal biofilms play a role in a variety of ocular infections.Filamentous fungal biofilms may participate in ocular infections by allowing filamentous fungi to persist on abiotic surfaces that come in contact with the eye,and by direct biofilm formation on biotic surfaces of the eye.This review discusses the current understanding of the basic biology and clinical implications associated with filamentous fungal biofilms in ophthalmology.