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IL-33与皮肤炎症性疾病关系的研究进展 被引量:7

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摘要 IL-33是IL-1细胞因子超家族的成员,组成性的表达于多种人类组织的细胞上,在皮肤组织细胞上呈现高表达。IL-33的特异性受体是转硫酶同系物(ST2),主要表达在Th2细胞、肥大细胞、巨噬细胞、树突状细胞、NK细胞和自然杀伤性T细胞等免疫细胞表面。IL-33的经典信号途径是通过ST2配体(ST2L)和IL-1受体辅助蛋白(IL-1RAP)组成的异二聚体,将信号转导至细胞内。IL-33是一种双效型的细胞因子,与皮肤多种炎症性疾病密切相关,尤其是银屑病和特应性皮炎,本文对IL-33及其在皮肤相关炎症性疾病的研究进展进行了综述。
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2014年第9期1000-1003,共4页 Chinese Journal of Cellular and Molecular Immunology
基金 河南省科技厅科技攻关项目(114300510012) 新乡医学院博士启动基金(BSQD2013008)
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同被引文献68

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