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肿瘤相关中性粒细胞的研究新进展 被引量：2

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摘要 肿瘤相关中性粒细胞(TAN)来源于血液中的中性粒细胞,进入肿瘤组织后,在细胞因子的刺激下,可极化为"N1"型或"N2"型中性粒细胞,"N1"型能够抑制肿瘤生长,"N2"型通过产生促肿瘤生长因子促进肿瘤生长及转移。临床研究表明,在多种不同的肿瘤患者中,TAN与肿瘤预后密切相关。因此,基于TAN对肿瘤的双面性,研究如何调控TAN的极化类型可为肿瘤免疫治疗提供新的靶点。本文综述了肿瘤相关中性粒细胞的研究进展。
作者 张庆勇 罗春华 王群兴
机构地区 三峡大学第一临床医学院宜昌市中心人民医院检验科
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2014年第10期1114-1116,共3页 Chinese Journal of Cellular and Molecular Immunology
基金 国家自然科学基金青年基金(81202303)
关键词 肿瘤相关中性粒细胞 肿瘤相关中性粒细胞分型 肿瘤微环境 综述
分类号 R730.3 [医药卫生—肿瘤] R392.11 [医药卫生—免疫学]
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参考文献25

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细胞与分子免疫学杂志
2014年 第10期

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