DNA甲基化与microRNA

DNA Methylation and microRNAs

细胞中DNA甲基化和microRNA(miRNA)相互影响,并共同调控着下游靶基因的表达活性,在细胞生长代谢、免疫、肿瘤和心血管疾病等生理和病理过程中发挥重要作用。首先简要介绍DNA甲基化与miRNA的概况,然后分析了miRNA调控下的DNA甲基化改变,探讨了DNA甲基化影响miRNA的表达活性变化,并归纳了miRNA与DNA甲基化之间的反馈调控关系;最后对DNA甲基化和miRNA的应用前景进行了简单探讨。研究DNA甲基化与miRNA间的网络调控关系,可为表观调控机制在理论和实践中的深入研究和应用提供参考。

DNA methylation and microRNAs（ miRNAs） interact and regulate each other in cells,which co-regulate the expression of its downstream target genes,and play important functions in the physiological and pathological processes of cell growth,metabolism,immune,tumor and cardiovascular diseases,etc. The research situation of DNA methylation and miRNAs was summarized briefly. Then,DNA methylation changes under the regulation of miRNAs were analyzed; changes in miRNAs expression and activity under the regulation of DNA methylation were discussed. The feedback regulatory relationships between DNA methylation and miRNAs were also reviewed. Finally,the application prospects of DNA methylation and miRNAs were also discussed briefly. Studies on the regulatory network between DNA methylation and miRNAs,can supply references for further study and application of epigenetics.