摘要
Heart failure is the leading cause of mortality in the world and represents the fastest growing subclass of cardiovascular diseases. An increasing body of evidence indicates an important role for microRNAs （miRNAs） in the pathogenesis and progression of heart failure. miRNAs are a class of small non-coding RNAs about 20 to 24 nucleotides （nt） （a few less than 20 nt） to regulate target gene expression at the post-transcriptional level. Mature miRNAs are formed after shearing a period of hairpin loop structure, the length of 70-80 nt and single stranded RNA precursors （pre-miRNA） with Dicer or nuclease as similar as Dicer.
Heart failure is the leading cause of mortality in the world and represents the fastest growing subclass of cardiovascular diseases. An increasing body of evidence indicates an important role for microRNAs （miRNAs） in the pathogenesis and progression of heart failure. miRNAs are a class of small non-coding RNAs about 20 to 24 nucleotides （nt） （a few less than 20 nt） to regulate target gene expression at the post-transcriptional level. Mature miRNAs are formed after shearing a period of hairpin loop structure, the length of 70-80 nt and single stranded RNA precursors （pre-miRNA） with Dicer or nuclease as similar as Dicer.
