血必净注射液对全身炎症反应综合征患者免疫功能的调节作用

The Effect of Xuebijing Injection on Immune Regulation in SIRS Patients

目的研究血必净对全身炎症反应综合征（SIRS）患者的免疫调节作用。方法将2013年1~12月入住贵州省人民医院重症医学科的56例SIRS患者,按照随机原则,将其分为对照组（C组）和血必净治疗组（T组）。对照组实行常规治疗,血必净治疗组在常规治疗基础上加用血必净注射液50mL,每日2次。观察治疗前、治疗4d、治疗7d的CD4＋、CD8＋、CD4＋/CD8＋及CD14＋/人类白细胞相容性抗原-DR（HLA-DR）水平动态变化,并同时观察急性生理与慢性健康评分Ⅱ（APACHEⅡ评分）、心率、白细胞、体温、呼吸的变化以及多器官功能障碍综合征（MODS）的发生率。结果两组患者治疗前各项指标差异均无统计学意义（P〉0.05）;治疗4d、7d后,T组CD4＋、CD8＋、CD4＋/CD8＋及CD14＋/HLA-DR水平较C组改善,差异均有统计学意义（P〈0.05）;T组生命指标亦较C组改善（P〈0.05）;两组MODS的发生率差异无统计学意义（P〉0.05）。结论血必净注射液可调节SIRS患者的免疫状态,同时能改善患者的全身状况。

Objective To investgate the effect of Xuebijing Injection on immune regulation in patients with systemic inflammatory response syndrome（SIRS）.Methods 56 SIRS patients admitted to the ICU of Guizhou Provincial Hospital from January 2013 to December 2013 were included in this study.The patients were randomly divided into a control（C）and a treatment（T）group.Patients in C group received routine treatment;while patients in T group received additional Xuebijing Injection 50 mL Bid.The following indicators were recorded and compared between the two groups before and 4and 7days after treatments：CD4＋,CD8＋,CD4＋/CD8＋,monocytes CD14＋/human leukocyte antigen-DR（HLA-DR）,score of acute physiology and chronic health evaluationⅡ（APACHEⅡ）,heart rate,white blood cells,body temperature,respiration rate,and MODS（7dafter treatment only）.ResultsNo differences were found between the two groups before treatments（P〈0.05）.T Group had higher levels of CD4＋,CD8＋,CD4＋/CD8＋and monocytes CD14＋/HLA-DR than C group at 4and 7dafter treatments（P〈0.05）.T group also had higher levels of improvement in vital indicators compared with C group（P〈0.05）.No significant difference in incidence of multiple organ dysfunction syndrome（MODS）was found between the two groups（P〈0.05）.Conclusion Xuebijing Injection can regulate immune function of patients with SIRS.