2010-2012年山西省祁县人间布鲁杆菌感染情况调查

An investigation of human brucellosis infection in Qi County of Shanxi Province in 2010-2012

目的 了解祁县人间布鲁杆菌感染现状.方法 2010-2012年,在祁县选择布鲁杆菌病（简称布病）疑似患者,涉及牛、羊畜交易,屠宰,养殖,畜产品加工等重点职业人群作为调查对象.在调查对象知情同意后采集静脉血,采用虎红平板凝集试验（RBPT）和试管凝集试验（SAT）检测血清布鲁杆菌抗体.调查布病发病人群的性别、发病时间、职业、年龄.对部分SAT阳性患者进行血培养,分离布鲁杆菌并利用传统生物学特性鉴定方法进行菌型测定.结果 2010-2012年,共检测977人,确诊阳性病例273人,阳性率为27.9％,其中男性[31.6％（232/735）]高于女性[16.9％（41/242）,P＜0.05].每年的3-8月为高发季节,发病人群以从事养殖业者,且年龄在21～ 60岁的人群居多.30例经血培养分离到11株羊3型布鲁杆菌.结论 祁县布病感染与职业有关,发病人群以青壮年居多,男性居多,应加强健康教育,提高病区居民自我保护意识,降低布病的发生.

Objective To analyze the status of human brucellosis infection in Qi County.Methods From 2010 to 2012,by using Rose Bengal plate agglutination test （RBPT） and standard tube agglutination test（SAT）,serological detection was conducted in suspected brucellosis cases and risk populations occupational exposed to Brucella,including livestock traders,slaughters,raisers,milkmaids and veterinary in Qi County.The sex distribution,time distribution,occupation and age distribution were analyzed.Brucella were isolated from patients in acute stage by blood culture,and serotypos were determined by traditional identification method.Results From 2010 to 2012,977 people were examined; 273 people were serological positive（27.9%） ; male[31.6%（232/735）] was higher than female[16.9%（41/242）,P 〈 0.05].March to August were the peak seasons in every yeas.Most of the patients were engaged in farming,aged from 21 to 60 years old.Eleven strains of Brucella Melitensis biotype 3 were isolated in 30 cases of blood culture samples.Conclusions The incidence of human brucellosis is increasing year by year in Qi County.Infected people are mostly young men.It is necessary to strengthen health education,increase the awareness of self protection in order to reduce the occurrence of brucellosis.