摘要
目的研究CXCR7在胃癌组织中的表达,及其与胃癌生长、黏附及侵袭的关系。方法收集160例胃腺癌患者的癌组织(胃癌组)和30例正常胃组织(对照组),采用免疫组化方法检测CXCR7、Survivin、CD44v6、基质金属蛋白酶(MMP)-3在胃腺癌和正常组织中的表达,并分析其相关性。结果 CXCR7在胃腺癌组织中的表达明显高于对照组(P<0.05),并且其在胃癌中的表达则因胃癌肿块直径的大小、浸润深度、是否有淋巴结转移及临床分期不同而不同,差异有统计学意义(P<0.05)。在胃癌组中CXCR7表达与Survivin、CD44v6及MMP-3呈正相关。结论CXCR7通过抗凋亡因子Survivin参与胃癌的生长,在胃癌的黏附及侵袭过程中通过CD44v6及MMP-3发挥作用,并可能参与胃癌的淋巴结转移。
Objective To investigate the expression of CXCR7 in gastric carcinoma tissues and the role of CXCR7 in tumor growth, adhesion and invasion of gastric cancer. Methods The expression levels of CXCR7, Survivin, CD44v6 and matrix metalloproteinase （MMP）-3 were detected by immunnohistochemistry method in gastric cancer specimens came from 160 patients （gastric cancer group） and 30 specimens of normal gastric tissues （control group）. Results The expression of CXCR7 protein was significantly higher in gastric cancer group than that of control group （P＆lt;0.05）. The positive CXCR7 staining was significantly different with tumor size, depth of invasion, lymph node metastasis and clinical staging （ P＆lt;0.05）. CXCR7 expression was positively correlated with Survivin, CD44v6 and MMP-3. Conclusion CXCR7 might take part in progression of gastric cancer by anti-apoptosis （Survivin）. CXCR7 might take part in the lymph node metastasis of gastric cancer and mediate the adhesion and invasion by CD44v6 and MMP-3.
出处
《天津医药》
CAS
北大核心
2014年第9期870-873,共4页
Tianjin Medical Journal
基金
天津市滨海新区卫生局医药卫生科技项目(2011BHKY021)
天津市滨海新区大港区域社会发展科技项目(20120211)
天津市滨海新区科技发展战略研究计划项目(2012DK15W007)
