基因多态性对巯嘌呤类药物作用影响的研究进展

Recent progress in research and development of the impact of gene polymorphisms on thiopurine drugs

基因多态性是影响巯嘌呤类药物在体内代谢,最终造成药物疗效和毒性差异的主要原因。近年来研究发现,单一药物代谢酶或转运体的基因多态性与巯嘌呤类药物临床不良反应不完全相关,而多基因分析可能更好地解释患者对该药的不耐受原因。本文介绍了多种与巯嘌呤类药物有关的酶基因多态性的研究情况,同时就其代谢特点及与该药敏感性的关系进行综述。

Gene polymorphisms affect the metabolisms of thiopurine drugs, which eventu- ally become the main reason for the differences in efficacy and toxicity. Recently some resear- ches have showed that there were no complete correlations between a single gene polymorphism of drug metabolizing enzyme or transporter and clinical adverse reactions of thiopurine drugs. However, the reasons of drug intolerance wereprobably more related to multi-genetic analyses. In this article, some of the recent developments of gene polymorphisms of several enzymes about thiopurine drugs were introduced. Meanwhile, the relationships between their metabolic charac- teristics and drug susceptibility were reviewed.