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过敏性紫癜的发病机制及糖皮质激素在治疗中的地位 被引量：8

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摘要 过敏性紫癜（Henoch-Schnlein purpura,HSP）又称IgA血管炎,是儿童时期最常见的一种白细胞碎裂性小血管炎.尽管发病机制尚未完全阐明,但国内外研究认为HSP患者存在着体液免疫和细胞免疫的紊乱.HSP常为自限性疾病,约40％的患者在病发后4～6周进展为紫癜性肾炎（HenochSchnlein purpura nephritis,HSPN）.临床上对于糖皮质激素（glucocorticoid,GC）治疗HSP的意见仍未统一.所以有必要就HSP的病因学、发病机制及GC在治疗中的地位进行分析.
作者 刘德滢 鲁莹 刘敏 杨思睿
机构地区 吉林大学第一医院小儿风湿免疫科 长春市儿童医院小儿风湿免疫科
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2014年第9期640-642,共3页 Chinese Journal of Rheumatology
关键词 糖皮质激素 过敏性紫癜 发病机制 治疗 白细胞碎裂性 小血管炎 自限性疾病 紫癜性肾炎
分类号 R725.5 [医药卫生—儿科]
  • 相关文献

参考文献22

  • 1Mina C, Yukihiko K, Mariko K, et al. A 10-year-old girl with IgA nephropathy who 5 years later developed the charac- teristic feature of Henoch-Scht~nlein Purpura nephritis[J]. Fuku- shima J Med Sci, 2010, 56: 157-161.
  • 2Rlvarez-Caro F, Concha-Torre J, Garcia-Hernandez I, et al. Massive lower gastrointestinal haemorrhage, successfully treat- edwith cortieosteroids, as main symptom of Sch6nlein-Henoch purpura[J]. Reheumatol Int, 2009, 29: 1491-1494.
  • 3Yukihiko K. The pathogenesis and treatment of pediatric Henoch-Schonlein purpura nephritis[J]. Clin Exp Nephrol, 2011, 15: 648-657.
  • 4Keith K, Hitoshi S, Novak J, et al. Pathogenesis of Henoch- Sch~nlein purpura nephritis[J]. Pediatr Nephrol, 2010, 25: 19- 26.
  • 5Monteiro RC. The role of IgA and IgA Fc receptors in inflamma- tion[J]. J Clin Immunol, 2010, 30: 1-9.
  • 6Krzysztof K, Zina M, John T, et al. Aberrant Glycosylation of IgA1 is inherited in pediatric IgA nephropathy and henoch- schSnlein purpura nephritis[J]. Kidney, 2011, 80: 79-87.
  • 7Li PY, Lu L, Hu B. T-cell Immunoglobulin and Mucin-domain- containing Molecule-1 in Peripheral Blood Mononuclear Cell in Henoch-Schtinlein Purpura[J]. Indian Pediatrics, 2012, 49: 225- 227.
  • 8Chen T, Guo ZP,Li MM, et al. Tumour necrosis factor-like weak inducer of apoptosis (TWEAK), an important mediator of endo- thelial inflammation, is associated with the pathogenesis of Henoch-Schonlein purpura[J]. Clin Exper Immunol, 2011, 166: 64-71.
  • 9Chen T, Guo ZP, Li L, et al. TWEAK Enhances E-selectin and ICAM-1 Expression, and May Contribute to the Development of Cutaneous Vasculitis[J]. Plos One, 2013, 8: 1-11.
  • 10Takemitsu M, Tokuya O, Noriyasu S, et al. Clinical Signifi- cance of Blood Coagulation Factor & Activity in Adult Henoch- Scht~nlein Purpura[J]. J Nippon Med Sch, 2013, 80: 268-278.

二级参考文献23

  • 1殷蕾,周纬,金燕樑,杨珍,周征宇.糖皮质激素对过敏性紫癜患儿肾损害预防作用的Meta分析[J].临床儿科杂志,2007,25(2):147-150. 被引量：29
  • 2Butani L, Morgenstern BZ. Long-term outcome in childrenafter Henoch-Schonlein purpura nephritis [J], Clin Pediatr,2007, 46(6): 505-511.
  • 3Ronkainen J,Ala-Houhala M, Huttunen NP, et al. Outcomeof Henoch-Schonlein nephritis with nephritic-range proteinuria[J].Clin Nephrol, 2003,60(2): 80-84.
  • 4Buchanec J, Galanda V,Belakova S, et al. Incidence of renalcomplications in Schonlein-Henoch purpura syndrome independence of an early administration of steroids [J], Int UrolNephrol, 1988,20(4): 409-412.
  • 5Mollica F, Li Volti S, Carozzo R, et al. Effectiveness of earlyprednisoe treatment in preventing the development of nephropathyin anaphylactoid purpura [J]. Eur J Pediatr, 1992, 151(2): 140-144.
  • 6Saulsbury FT. Corticosteroid therapy does not prevent nephri-tis in Henoeh-Schonlein purpura [J]. Pediatr Nephrol, 1993,7(1): 69-71.
  • 7Huber AM, King J, McLaine P, et al .A randomized, placebo-controlled trial of prednisone in early Henoch Schonlein Pur-pura [J]. BMC Med., 2004,10(2): 1186-1195.
  • 8Ronkainen J, Koskimies O,Ala-Houhala M, et al. Early pred-nisone therapy in Henoch-Schonlein purpura: a randomized,double-blind, placebo-controlled trial [J]. Jpediatr, 2006,149(2): 241-247.
  • 9Dudley J,Smith G,Llewellyn-Edwards A, et al. Randomisedplacebo controlled trial to assess the role of early prednisoloneon the development and progression of Henoch-Schonlein Pur-pura Nephritis [J]. Pediatr Nephrol, 2007,22; 1457.
  • 10Bayrakci US, Topaloglu R, Soylemezoglu O, et al. Effect ofearly corticosteroid therapy on development of Henoch-Schon-lein nephritis [J]. J Nephrol, 2007, 20(4); 406-409.

共引文献15

同被引文献81

引证文献8

二级引证文献27

中华风湿病学杂志
2014年 第9期

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