ABCG2遗传多态性对阿托伐他汀降脂作用的影响

Effect of ABCG2genetic polymorphism on atorvastatin modifying serum lipids

目的:研究ATP结合盒转运子G2(ABCG2)遗传多态性对阿托伐他汀降脂作用的影响。方法:91例高脂血症患者,给予阿托伐他汀片(10mg/d)治疗8周。分别于治疗前及疗程结束时空腹抽血检测血脂[TC、TG、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDLC)]水平。采用焦磷酸测序法对ABCG2进行基因分型。结果:阿托伐他汀能显著降低不同基因型的LDL-C血浆水平(P<0.01),且CA、AA型患者降幅较CC型患者显著,差异具有统计学意义(P<0.05);阿托伐他汀能显著降低CA、AA型患者的TC、TG血浆水平,差异具有统计学意义(P<0.05)。结论:ABCG2遗传多态性能影响阿托伐他汀的降脂作用。

AIM- To study the correlation be- tween ABCG2 genetic polymorphism and the lip- id-lowering effect of atorvastatin. METHODS： Ninety-one aged patients with hypercholesterol- emia were enrolled. Atorvastatin （10 mg/d） was given for treatment during 8 weeks. All patients＇ serum level of TC, TG, LDL-C and HDL-C be- fore and after the 8 weeks treatment was tested. Pyrosequencing was technique was adopted to analyze ABCG2 gene of the patients. RESULTS： Atorvastatin may significantly decrease the plas- ma levels of LDL-C in different polymorphisms（P〈0.01）. And the plasma levels of LDL-C in CA and AA genotype patients decline than CC genotype patients （P〈0.05）. Atorvastatin may significantly reduce the TC and TG plasma levels in patients with CA and AA genotype patients （P〈 0.05）. CONCLUSION： ABCG2 genetic polymorphism may influence atorvastatin treat- ment.