中药注射剂药物代谢动力学研究现状

Current advancement on pharmacokinetics study of herbal injection prescription

中药注射剂的安全性问题正受到越来越多的关注。药代动力学研究是揭示中药注射剂效应物质基础及其体内过程的重要途径,对于临床合理用药、提高中药注射液质量控制标准与临床用药的有效性、安全性具有十分重要的意义。本文简要分析了中药注射剂药物代谢动力学研究相关进展,指出对中药注射液药代动力学的重视程度尚有待提高。随着近年来中药药代动力学研究技术方法的进步,已逐步具备条件开展中药注射液的体内过程研究,中药注射液的质量控制、安全性评价、工艺优化以及临床合理用药研究等方面应充分利用和结合中药注射液体内过程的研究结果,以保障和提高中药注射液临床用药的有效性与安全性。

The problem of medication safety about herbal injections has gained more and more attention. Pharmacokinetics is not only an important way to reveal the pharmacodynamic material basis and in vivo behavior of herbal in- jections, but also significant to improve the quality control standards and rational clinical use. This reveal makes a simple introduction a- bout research status of herbal injection pharma- eokinetics and indicates that the attention paid to the study is still limited. In recent years, the re- search of in vivo process about herbal injectionscould be carried out as the progress of TCM pharmacokinetics. The study of quality control, safety evaluation, process optimization and clini- cal rational drug use of herbal injections should use the results of the in vivo research to improve and guarantee the efficacy and safety of the in- jections.