玉泽皮肤屏障修护剂对儿童特应性皮炎的干预治疗

Intervention of Yuze Skin Barrier Repair Agent on Atopic Dermatitis in Children

目的观察玉泽皮肤屏障修护剂在儿童特应性皮炎治疗中作用。方法将67例特应性皮炎患者随机分为治疗组和对照组。对照组34例,外涂糠酸莫米松乳膏1次/d,2周后隔日1次,治疗4周,观察8周;治疗组33例,同时将玉泽皮肤屏障修护剂涂于患处及皮肤特别干燥部位2次/d,连用8周。分别于治疗后第1、2、4和8周对患儿进行随访。结果第1周2组比较差异无统计学意义(P>0.05),第2、4周,治疗组较对照组疗效显著,2组比较差异均有统计学意义(P<0.05)。治疗组患儿皮肤干燥程度均较治疗前明显好转,与对照组各时间段之间比较差异均有统计学意义(P<0.05)。第8周复诊时,2组临床治愈患者治疗组7例复发,对照组10例复发,2组比较差异有统计学意义(P<0.01)。结论玉泽皮肤屏障修护剂在儿童特应性皮炎治疗中明显改善皮肤屏障功能,提高疗效,降低复发率。

Objective To observe the role of Yuze skin barrier repair agent in the treatment ot children with atoplcdermatitis （AD）. Methods 67 eases of AD patients were randomly divided into treatment group and control group. Controlgroup of 34 patients were treated with mometasone furoate cream once daily for two weeks, and then once two days for twoweeks. Treatment group of 33 patients applied Yuze to skin twice daily for eight weeks, especially dry areas. After treatment,children were followed up in the first, second, fourth and eighth weeks respectively. Results The efficacy between the twogroups was not statistically significant （P〉0.05） in the first week, while in the second and fourth weeks, the treatment group hada significant effect compared with the control group, and between them there was the statistically significance （P〈0.05）. Thedryness of skin in treatment group was significantly improved than before, compared with the control group, and there werestatistically significant differences （P〈0.05） between them at each period. During the return visit in the eighth week among theclinically cured patients, seven patients relapsed in the treatment group and ten in the control group, and there was significantdifference （P〈0.01）. Conclusion Yuze skin harrier repair agent can improving skin barrier significantly, enhancing theefficacy and reducting the relapse rate in the treatment of children with AD.