FBXO31、Cyclin D1在胃癌中的表达及其临床意义

Expression and Clinical Significance of FBXO31 and Cyclin D1 in Gastric Cancer

目的:研究胃癌组织中FBXO31与Cyclin D1的表达以及二者与临床资料的相关性。方法:收集112例胃切除术患者胃癌组织及正常胃组织,采用免疫组化链霉亲和素-生物素-过氧化物酶复合物(SABC)法检测组织中FBXO31和Cyclin D1的表达,分析二者与胃癌临床病理特征的关系以及两者表达的相关性。结果:胃癌组织中FBXO31和Cyclin D1的阳性表达率分别为35.7%和75.9%,与癌旁正常组织中FBXO31和Cyclin D1的表达(分别为73.2%和26.8%)具有显著性差异(P均<0.001)。FBXO31和Cyclin D1在胃癌组织的表达与有无淋巴结转移、TNM分期以及肿瘤大小显著相关(P均<0.05)。且Cyclin D1表达与有无腹膜播散亦显著相关(P<0.05)。但二者的表达与患者年龄、性别并无相关性。FBXO31和Cyclin D1的表达呈显著负相关性(P<0.001,!=0.58)。结论:胃癌组织中FBXO31表达降低,Cyclin D1表达增高,二者在胃癌的发生、发展、侵袭和转移进程中可能发挥重要作用。

Objective：To study expression of FBX031 and Cyclin D1 in relation to the clinicopathological features in gastric cancer.Methods：SABC method was used to detect the expression of FBXO31 and Cyclin D1 in 112cases of gastric cancer,and the relationship between FBXO31/Cyclin D1 expression and clinicopathological features were analyzed.Results：The positive expression rate of FBXO31 and Cyclin D1 was 35.7% and 75.9%respectively in gastric cancer tissue,which had significant differences as compared with that in the normal tissue（versus 73.2%and 26.8%,respectively,P〈0.001）.The expression rates of FBXO31 and Cyclin D1 were correlated with lymph node metastasis,tumor size and TNM stage（all P〈0.05）.Moreover,the expression of FBXO31 and Cyclin D1 were correlated with peritoneal dissemination（P〈0.05）.There was no significant correlation between FBXO31/Cyclin D1 expression and patient age and sex.There was a significant correlation between the expression of FBXO31 and Cyclin D1.Conclusion：FBXO31was lower-expressed and Cyclin D1 was over-expressed in gastric cancer.They may play an important role in the process of genesis,development,invasion and metastasis of gastric cancer.