艾司洛尔联合胺碘酮治疗急性冠脉综合征后心室电风暴的疗效观察

Curative Effect of Combined Esmolol and Amiodarone on Ventricular Electrical Storm in Patients with Acute Coronary Syndrome

目的:探讨艾司洛尔联合胺碘酮治疗急性冠脉综合征(ACS)后心室电风暴的临床疗效。方法:选择ACS后并发心室电风暴患者45例,随机分成胺碘酮治疗组(20例)和艾司洛尔联合胺碘酮治疗组(25例);观察两组治疗前后的有效率,收缩压、舒张压、心率及QT离散度的变化并评估其安全性。结果:联合治疗组的有效率92%显著高于胺碘酮治疗组(65%)(P<0.05);联合治疗组心率及QT离散度显著低于胺碘酮治疗组(P<0.05);联合治疗组与胺碘酮治疗组的安全性无显著差异。结论:艾司洛尔联合胺碘酮治疗急性冠脉综合征后心室电风暴效果显著,值得临床推广。

Objective： To observe the curative effect of combined esmolol and amiodarone on ventricular electri cal storm in the patients with acute coronary syndrome （ACS）. Methods： Forty-five cases of ventricular electrical storm in the patients with ACS were randomly divided into two groups as amiodarone group （n =30） and esmolol plus amiodarone group （n=25）. The success rate of electroversion and adverse reactions were recorded, systolic blood pressure（$BP）, heart rate （HR）, and QTd were measured and compared between the two groups. Results： The success rate of terminating VT and VF was significantly higher in combined group than in amiodarone group （92% vs. 65%, P〈0.05）. The HR and the QTd in combined group were lower than those in amiodarone group （P〈0.05）. Conclusion： The intravenous injection of combined esmolol and amiodarone is a safe and effective treatment strategy for trea ting ventricular electrical storm in the patients with ACS.