无催化剂条件下有效的四组分反应合成2,3-二氢噻吩衍生物

An Efficient Synthesis of 2,3-Dihydrothiophene Derivatives from Four-Component Reactions under Catalyst-Free Conditions

芳香醛、2,4-噻唑烷二酮、丙二腈和3-吡啶甲胺于95%乙醇中四组分反应,方便地获得一系列新的2,3-二氢噻吩衍生物.这是杂环胺类化合物首次应用于噻吩衍生物的合成,具有反应条件温和、容易操作、产率高等优点.产物的结构经过红外、核磁和高分辨质谱确定.

An efficient synthesis of 2,3-dihydrothiophene derivatives by the four-component reactions of aromatic aldehydes, thiazolidine-2,4-dione, malononitrile and pyridin-3-ylmethanamine has been reported. This reaction could be carried out smoothly without using any other catalysts in ethanol （95%） and the aromatic heterocyclic amine （pyridin-3-ylmethanamine） was first used for the synthesis of 2,3-dihydrothiophene derivatives. The advantages of this procure were mild reaction condi- tions, easy operation, and high yields. The products were identified by IR, XH NMR and HRMS.