葛根芩连汤加减对颈动脉粥样硬化斑块的临床研究

The Clinical Research of Gegen Qinlian Decoction on Carotid Artery Atherosclerosis

目的:观察葛根芩连汤加减治疗颈动脉粥样硬化斑块的疗效。方法:选取2010-2012年在本院就诊的48例颈动脉粥样斑块患者,按照随机数字表法将其分为治疗组和对照组各24例,治疗组给予葛根芩连汤加减治疗,对照组给予口服辛伐他汀治疗,观察比较两组患者治疗前与治疗6个月后颈动脉IMT、course积分、血脂情况、CRP及颈动脉中医证候积分。结果:与治疗前比较,两组治疗6个月后的颈动脉IMT、crouse积分、TC、TG、LDL、CRP及中医证候积分均明显降低(P<0.05),HDL明显升高(P<0.05),且治疗组的crouse积分、CRP及中医证候积分均明显低于对照组(P<0.01),而两组上述其余指标均无明显差异(P>0.05)。结论:葛根芩连汤具有良好的抗动脉粥样硬化作用,值得临床推广。

Objective：To observe the effect of Gegen qinlian decoction in treatment of carotid artery atherosclerosis.Method：Forty-eight patients with carotid artery atheromatous plaque in our hospital from 2010 to 2012 were selected,they were divided into the treatment group and the control group according to the random number table method,24 cases in each group.The treatment group was given Gegen qinlian decoction and the control group wan given Simvastatin.The carotid artery intima-medial thickness,crouse plaque integral,serum lipids,CRP and TCM Syndromes of carotid artery of the two groups before and after 6 months of treatment were observed and compared.Result：Compared with before treatment,the carotid artery intima-medial thickness,crouse plaque integral,TC,TG,LDL,CRP and TCM Syndromes of carotid artery after 6 months of treatment were significantly lower than before treatment（P〈0.05）,HDL was significantly higher than before treatment（P〈0.05）,and crouse plaque integral,CRP and TCM Syndromes of carotid artery in treatment group were significantly lower than those in control group（P〈0.01）.And there were no significant differences in the remainder of the index between the two groups（P〉0.05）.Conclusion：Gegen qinlian decoction has a good anti-atherosclerosis effect,is worthy of clinical promotion.