血清降钙素原对儿童发热性疾病的诊断及临床意义

Significance of Detection of Serum Procalcitonin in Diagnosis of Febrile Diseases

目的:探讨血清降钙素原(PCT)、外周血白细胞(WBC)和C-反应蛋白(CRP)水平在儿童发热性疾病中的临床意义及指导抗生素的应用。方法:以河南大学淮河医院儿科2012年5月-2013年5月收治的150例发热患儿为研究对象,采用回顾性分析方法,根据出院时的诊断分为细菌感染组、非细菌感染组。检测其外周血WBC、血清PCT及CRP,并与对照组40例非发热性疾病患儿进行比较。结果:细菌感染组、非细菌感染组及对照组患儿WBC数分别为(16.37±4.60)×109/L、(11.62±5.13)×109/L、(7.09±1.88)×109/L;CRPm值分别为(18.07±10.67)mg/L、(8.23±2.49)mg/L、(5.01±2.84)mg/L;PCT值分别为(2.54±2.24)μg/L、(0.11±0.05)μg/L、(0.09±0.05)μg/L。细菌感染组外周血WBC、血清PCT及CRP均明显升高,非细菌感染组外周血WBC轻度升高,血清PCT及CRP均无明显升高。结论:联合应用外周血WBC、血清PCT及CRP对儿童发热性疾病的鉴别诊断及抗生素的应用有重要意义。

Objective： To investigate the level of procalcitonin（PCT） and peripheral blood white blood cells（WBC） and C-reactive protein（CRP） in the monitoring of febrile diseases and antibiotics. Method： The clinical data of 150 were divided into bacterial infection group（60 cases） and non-bacterial infection group（90 cases） at our hospital from May 2012 to May 2013. 40 cases with non-infection were set as control group. Result： The WBC of the three groups was（16.37±4.60）×10^9/L,（11.62±5.13）×10^9/L,（7.09±1.88）×10^9/L. The date of CRP of the three groups was（18.07±10.67）mg/L,（8.23±2.49）mg/L,（5.01±2.84）mg/L. The date of PCT of the three groups was（2.54±2.24）μg/L,（0.11±0.05）μg/L,（0.09±0.05）μg/L. The serum PCT and CRP levels and WBC of the bacterial infection group were higher significantly than those of the non-bacterial infection group and the control group. Conclusion： It is feasible that PCT, CRP and WBC can be as important markers for the febrile diseases and also potential application of antibiotics for the judgement of the infection.