丹参酮ⅡA璜酸钠注射液治疗脑梗死的临床疗效观察

The Observation on Clinical Efficacy of Tanshinone ⅡA Sulfoacid Sodium Injection in Treatment of Cerebral Infraction

目的:观察并分析丹参酮ⅡA璜酸钠注射液治疗脑梗死的临床效果。方法:选取2011年1月-2014年1月本院诊治的62例脑梗死患者的临床资料,按照完全随机法1:1分成对照组和研究组各31例,对照组行常规西医对症治疗,研究组在对照组基础上加用丹参酮ⅡA璜酸钠注射液,观察比较两组患者的神经功能与生活能力改善,自由基与血液流变学指标水平变化情况。结果:与治疗前比较,两组治疗后的SOD活性均明显升高,MDA与LPO水平均明显降低(P<0.05)。研究组治疗后的SOD活性(5.96±0.13)U/mL明显高于对照组的(4.85±0.11)U/mL,MDA水平(8.36±0.93)mmol/mL与LPO水平(10.57±2.16)mmol/mL均明显低于对照组(10.54±0.52)mmol/mL和(13.25±2.61)mmol/mL,差异均有统计学意义(P<0.05)。治疗2周、4周时,两组NIHSS、NDS评分均明显降低,ADL、BI评分均明显升高,且同期组间比较差异显著,均有统计学意义(P<0.05);研究组治疗后的全血比粘度、血浆比粘度与红细胞聚集指数均明显低于治疗前与同期对照组,差异均有统计学意义(P<0.05)。结论:丹参酮ⅡA璜酸钠注射液治疗脑梗死的临床效果显著,值得临床推广与应用。

Objective： To observe and analyze the clinical effect of tanshinone ⅡA sulfoacid sodium injection in treatment of cerebral infraction.Method ： 62 patients with cerebral infraction .treated in our hospital from January 2011 to January 2014 were selected and divided into the research group and the control group according to completely randomized method 1 ： 1, 31 cases in each group.The control group was treated with routine Western Medicine, the research group was treated with tanshinone ⅡA sulfoacid sodium injection on the basis of control group, the neurological function and improvement of viability, free radical and hemarheology indicators change of the two groups were observed and compared.Result： Compared with before treatment, the SOD activity of two groups after treatment were significantly higher, MDA and LPO levels were significantly decreased （ P〈0.05 ） .The SOD activity of research group after treatment was （ 5.96 ± 0.13 ） U/mL, it was significantly higher than （ 4.85 ± 0.11 ） U/mL of control group, the MDA level was （ 8.36 ± 0.93 ） mol/mL and LPO level was （ 10.57 ± 2.16 ） mol/mL, they were significantly lower than （ 10.54 ± 0.52 ） mol/mL and （ 13.25 ± 2.61 ） mol/mL control group, the differences were statistically significant （ P〈0.05 ） .When the patients were treated for 2 weeks and 4 weeks, NIHSS and NDS score of two groups reduced, and ADL and BI score increased, and the differences between two groups were evident, which had statistical significance （ P〈0.05 ） .The whole blood relative viscosity, plasma specific viscosity and aggregation index of red cells after treatment of the research group were significantly lower than those of before treatment and control group, the differences were statistically significant （ P〈0.05 ） .Conclusion： Tanshinone ⅡA sulfoacid sodium injection in treatment of cerebral infraction has evident clinical effect, which is worthy of clinical promotion and application.