银杏达莫针剂对急性肺损伤兔肺组织氧自由基的影响

EFFECTS OF GINKGO DIPYRIDOLUM INJECTION ON OXYGEN FREE RADICALS OF THE LUNG TISSUE IN RABBITS WITH ACUTE LUNG INJURY

目的观察银杏达莫针剂对油酸所致急性肺损伤氧自由基的影响。方法 24只家兔随机分为3组:假手术组、油酸模型组及银杏达莫治疗组,每组8只。连续监测并记录造模前、造模和治疗后1、2、3、4 h的心率、平均动脉压的变化;实验结束时测定肺组织湿、干重量,计算湿/干重比,并取肺组织检测丙二醛(MDA)和超氧化物歧化酶(SOD)。结果银杏达莫组外周血管阻力降低;银杏达莫组与模型组比较,可以降低MDA(p<0.05)和升高SOD(p<0.05),减轻肺组织湿/干比(p<0.05)。结论银杏达莫针剂可减轻油酸所致急性肺损伤的氧化应激作用。

Objective To observe the effects of Ginkgo dipyridolum injection on oxygen free radicals in rab- bits with acute lung injury （ALI） induced by oleic acid （OA）. Methods 24 rabbits were randomly divided into three groups： sham operation group, OA model group and ginkgo dipyridolum （GLE -DD） group in equal number. The changes of the heart rate and mean arterial pressure （MAP） before and after making model and at hours 1,2, 3 and 4 after treatment were constantly monitored and recorded. At the end of the experiment, the wet weight and dry weight of the lung tissue was detected to count wet -to -dry （W/D） weight ratio. The MDA and SOD in the lung tis- sue were tested. Results The peripheral vascular resistance was decreased in GLE - DD group. In comparison with the model group, the level of MDA was decreased （p 〈0.05） and the level of SOD was increased（p 〈0.05） in GLE - DD group. The W/D weight ratio of the lung tissue was reduced in GLE - DD group （p 〈 0.05 ）. Conclusion Ginkgo dipyridolum injection can alleviate the oxidative stress in OA - induced ALI.