鸡脾转移因子对传染性法氏囊疫苗的作用

Effects of Chicken Spleen Transfer Factor on Infectious Bursal Vaccine

中等偏弱毒力的传染性法氏囊病毒(IBDV)疫苗免疫鸡不产生免疫抑制而中等毒力以上的传染性IBDV疫苗免疫时会导致鸡不同程度的免疫抑制,给养禽业造成很大的经济损失,为了试验转移因子(TF)拮抗这种免疫抑制的作用,将180只试验AA肉鸡10日龄雏鸡分为6组,每组30只,其中第6组为对照组.第1组免疫中等偏弱Bj836株IBDV疫苗,第2、3、4、5组鸡在10日龄时免疫中等毒力B87株IBDV疫苗,其中第3、4、5组使用不同剂量的TF.免疫24h后,6组鸡均免疫新城疫(ND)疫苗.在鸡17日龄、24日龄、31日龄时,各组随机抽取鸡检测免疫器官指数和ND抗体水平.试验结果显示:第3、4、5组鸡免疫器官指数及ND抗体水平明显高于第2组,且分别稍低、接近、高于健康鸡第6组.表明了TF可拮抗IBDV免疫时引起的免疫抑制,效果显著.

In recent years,immune suppression caused by infectious bursal vaccine（IBDV）in chickens has attracted our attention.Chickens immunized moderate attenuated virulence IBDV vaccine do not produce immunosuppression while chickens immunized moderate virulence IBDV vaccine will produce different degrees of immunosuppression.This experiment is to explore the effect of transfer factor（TF）antagonizing immunity suppression.180 AA broilers were randomly divided into 6groups including group 6as a blank control.Group 1chickens were inoculated moderately attenuated IBDV vaccine Bj836.Four other groups＇ chickens were inoculated moderate virulence IBDV vaccine B87 while the group3、4and 5were given different doses of TF.All administrated groups were inoculated newcastle disease vaccine after 24 h.Through detecting immune organ index and newcastle disease antibody level of different groups＇ chickens at the age of 17,24 and 31.Results suggested that the immune organ index and ND antibody levels of group3,group 4and group 5was much higher than the group 2and was lower,loser,higher than group6.Therefore,TF can antagonize the immune suppression caused by IBDV.