高龄男性2型心肾综合征患者血清睾酮水平的研究

Serum testosterone level in elderly male patients with type 2 cardiorenal syndrome

目的:观察高龄男性2型心肾综合征患者血清睾酮水平的变化。方法:入选年龄≥75岁的慢性心力衰竭男性患者150例,将其中2型心肾综合征者设为观察组(n=69),其余设为对照组(n=81)。检测并比较两组患者血清睾酮、胱抑素-C、N末端B型利钠肽原(NT-proBNP)、超敏C反应蛋白等指标。结果:观察组血清胱抑素-C、NTproBNP、超敏C反应蛋白水平均高于对照组(P<0.05)而血清睾酮水平显著低于对照组,为(12.7±6.08)nmol/L对(22.07±7.53)nmol/L,P<0.01;其余指标组间均无统计学差异。结论:高龄男性慢性心力衰竭患者中,发生2型心肾综合征者血清睾酮水平降低。

Objective：To observe the change of serum testosterone levels in elderly male patients with type 2 cardiorenal syndrom （CRS）. Methods：A total of 150 male patients with chronic heart disease over the age of 75 selected into this study were assigned to observation group （type 2 CRS,69 cases）and control group （non-type 2 CRS,81 cases）.Serum testosterone,cystatin-C,N-terminal pro-brain natriuretic peptide （NT-proBNP）,high sensitivity C-reactive protein （hs-CRP）and some other serological indexes were determined. Resuits：The serum levels of cystatin-C,NT-proBNP and hs-CRP were all higher （P 〈0.05）,but serum testosterone was significantly lower[（12.7 ±6.08）nmol/L vs. （22.07±7.53）nmol/L,P 〈0.01 ]in observation group than those in control group. Conciusion：The serum testosterone level may decrease in elderly male patients with type 2 CRS.