Rasmussen脑炎的研究现状

Present status of rasmussen encephalitis

Rasmussen脑炎是一种散发的起病于儿童期的病因未明的疾病,以难治性癫痫、智能下降及偏瘫为临床特点。该疾病一般侵犯一侧半球,目前病因未明。抗癫痫药不能控制该疾病发展及进程,激素冲击或免疫球蛋白治疗也仅对部分患者起到短时的缓解作用,病变侧的大脑半球切除手术是目前唯一有效的治疗办法。

Rasmussen's encephalitis is a rare progressive encephalitis that results in intractable seizures,cognitive decline,and hemiparesis.The affected hemispheres of RE patients are typically unilateral.There is no conclusive evidence elucidating RE etiology.To date,no antiepileptic drug has been demonstrated to be effective for controlling the disease or stopping its progression.Immunoglobulins and high doses of steroids may be transiently helpful in some patients at an early stage.Only hemispherectomy are useful methods to control seizures in RE patients.