自制肠外营养剂对妊娠剧吐的疗效及妊娠结局的影响

Efficacy of Self- Made Parenteral Nutrient on Hyperemesis Gravidarum and Impact on Pregnant Outcome

目的探讨自制肠外营养剂对妊娠剧吐的作用及其对妊娠结局的影响。方法选择医院收治的妊娠剧吐患者64例,随机分为对照组和治疗组,各32例。治疗组采用自制肠外营养剂经外周静脉输液,对照组采用常规的输液疗法。结果治疗组的止吐总有效率为87.50%,明显高于对照组的34.38%(P<0.05);治疗组血糖和前白蛋白水平改善显著优于对照组(P<0.05);两组患者的体重无明显差异(P>0.05);治疗组患者血钾、尿酮体回归正常时间、平均住院时间均明显短于对照组(P<0.05);两组患者均未见明显不良反应。两组流产、死胎的例数无显著性差异(P>0.05),但治疗组新生儿体重为(3.5±0.6)kg,明显高于对照组的(2.9±0.4)kg(P<0.05)。结论自制肠外营养剂治疗妊娠剧吐有良好的疗效,可促进尿酮体转阴,增加新生儿体重,对妊娠结局无不良影响。

Objective To investigate the efficacy of self- made parenteral nutrient on hyperemesis gravidarum and the impact on pregnancy outcome. Methods 64 cases of hyperemesis gravidarum in our hospital were selected and randomly divided into the control group and the treatment group, 32 cases in each group. The observation group was treated by self-made parenteral nutrient by peripheral intravenous infusion and the control group adopted the conventional infusion therapy. Results The total effective rate of vomit- stopping in the treatment group was 87.50%,which was significantly higher than 34.38% in the control group（P 〈 0. 05）. the body weight had no statistical difference between the two groups; the time of blood potassium and urine acetone bodies recovering to normal levels, average hospitalization time in the treatment group were significantly shorter than those in the control group（P〈0. 05）;no obvious adverse reactions were found in the two groups, the cases of abortion and dead fetus had no statistical difference between the two groups（P〉0. 05）,but the neonatal birth weight in the treatment group was （3.5 ±0.65）kg, which was significantly higher than （2. 9 ±0. 45）kg in the control group（ P 〈 0. 05）. Conclusion Self- made parenteral nutrient has better effect in treating hyperemesis gravidarum, can promote the negative conversion of urine acetone bodies and increase the neonatal body weight without adverse effects on pregnancy outcome.