COPD患者呼出气冷凝液中多项因子检测及与肺功能的相关性分析

Correlative analysis between EBC levels of IL-6,IL-8,hsCRP,TNF-α and pulmonary function in patients with COPD

目的探讨健康对照组、COPD稳定期组和COPD急性加重组中hsCRP、TNF-α、IL-6、IL-8水平变化及与肺功能的相关性。方法纳入30例健康者、28例COPD稳定期患者和30例COPD急性加重期患者作为研究对象,测定EBC中hsCRP、TNF-α、IL-6、IL-8的浓度,以及与第1秒用力呼吸量占预计值的百分比的相关分析。结果 (1)COPD急性加重组中hsCRP、TNF-α、IL-6、IL-8水平高于COPD稳定期组,差异具有显著性(P<0.05)。(2)COPD稳定期组hsCRP、TNF-α、IL-6、IL-8水平均高于对照组,差异具有显著性(P<0.05)。(3)COPD急性加重组中TNF-α、IL-6、IL-8水平均与FEV1%呈负相关(P<0.05),而hsCRP与FEV1%则无明显相关性。结论 COPD气道炎症与hsCRP、TNF-α、IL-6、IL-8水平释放增多有关,检测EBC中hsCRP、TNF-α、IL-6、IL-8水平可作为判断COPD病情及预后的指标。

Objective To investigate the relationship between EBC levels of interleukin-6 （IL-6）, interleu-kin-8 （IL-8）, hsCRP, TNF-α and pulmonary function in patients with COPD. Methods The levels of hsCRP, TNF-α, IL-6 and IL-8 were detected from 30 cases of normal volunteers, 28 cases in stable period of COPD and 30 cases of acute exacerbation of COPD. FEV1% was correlated analyzed. Results （1） The levels of hsCRP, TNF-α, IL-6 and IL-8 in patients with AECOPD were significantly higher than those in stable period of COPD （ P〈0. 05 ） . （2） The levels of hsCRP, TNF-α, IL-6 and IL-8 in patients with stable period of COPD were significantly higher than those in normal volunteers （P〈0. 05）. （3） The level of TNF-α, IL-6 and IL-8 in patients with AECOPD were negatively correlated with FEV1% （P〈0. 05）. But the level of hsCRP had no relation with FEV1%. Conclusion The increased levels of hsCRP, TNF-α, IL-6 and IL-8 play certain role in acute exacerbation of COPD, which can be indicators in judging the prognosis of COPD.