COPD患者CRP、IL-6、IL-10水平与心血管事件的相关性

Correlation between the levels of CRP,IL-6,and IL-10 and cardiovascular events in COPD patients

目的探讨COPD患者CRP、IL-6、IL-10水平与其心血管事件的相关性。方法选择2013年5月至2014年2月我院收治的60例伴有心血管疾病的COPD老年患者作为观察组,并选择同期60例无合并心血管疾病的COPD老年患者作为对照组。通过放免法检测两组患者体内CRP、IL-6、IL-10水平观察其与患者心血管事件的相关性。结果观察组CRP、IL-6分别为(16.4±2.6)ng/L和(12.8±0.6)mg/L,显著高于对照组,差异具有统计学意义(P<0.05);观察组IL-10水平为(8.4±1.2)ng/L,显著低于对照组,差异具有统计学意义(P<0.05);随着病情程度加重,CRP、IL-6水平逐渐增加,重度患者含量明显高于轻度患者(P<0.05);IL-10水平随着程度加重而降低,重度患者明显低于轻度(P<0.05)。结论合并心血管疾病的COPD患者体内炎症反应明显,炎症因子CRP、IL-6升高,抗炎因子IL-10降低,因此检测细胞因子水平在一定程度上可反映病情程度。

Objective To investigate the correlation between the levels of CRP, IL-6 and IL-10 and cardio-vascular events in COPD patients. Methods 60 elderly COPD patients with cardiovascular disease were selected as the observation group from May 2013 to February 2014 in our hospital, and another 60 COPD elderly patients without cardiovascular disease at the same period were selected as the control group. The levels of CRP, IL-6 and IL-10 were detected by radioimmunoassay. The correlation was observed between the levels of CRP, IL-6 and IL-10 and cardio-vascular events in COPD patients. Results The levels of CRP and IL-6 were （16. 4 ± 2. 6） ng/L and （12. 8 ± 0. 6） mg/L respectively in the observation group, which were significantly higher than those in the control group （ P 〈0. 05）. The level of IL-10 in the observation group was （8. 4 ± 1. 2） ng/L, significantly lower than that in the control group （P〈0. 05）. With the increase of disease severity, the levels of CRP and IL-6 increased gradually, and the level of IL-6 decreased significantly （P〈0. 05）. Conclusion There exists clear inflammation reaction in COPD pa-tients complicated with cardiovascular disease, that is the levels of CRP and IL-6 increases and the level of IL-10 de-creases.