阿托伐他汀钙对冠心病颈动脉粥样硬化患者颈动脉粥样硬化斑块的影响

Atorvastatin Calcium on Coronary Heart Disease Patients with Carotid Atherosclerotic Carotid Atherosclerotic Plaque

目的探讨冠心病颈动脉粥样硬化患者给予阿托伐他汀钙治疗对颈动脉粥样硬化斑块的影响。方法收集冠心病颈动脉粥样硬化患者45例,均给予阿托伐他汀钙口服治疗。观察血脂水平变化和颈动脉粥样硬化斑块变化。结果治疗后2、4、12周时患者TC、TG、LDL-C等指标水平明显下降,HDL-C明显上升;治疗后颈动脉内膜中层厚度(IMT)、斑块总面积和斑块总得分均低于治疗前,差异均具有统计学意义(P<0.05)。结论在冠心病颈动脉粥样硬化的临床治疗中进行调脂治疗可改善粥样硬化斑块,对患者的预后具有积极的临床意义。

Objective To investigate the carotid atherosclerotic coronary artery disease patients given atorvastatin calcium treatment of carotid atherosclerotic plaques.Methods 45 patients with carotid atherosclerotic coronary artery disease, were given oral treatment of atorvastatin calcium. To observe the blood lipid level changes and carotid atherosclerotic plaques.Results After treatment for 2, 4, 12 weeks in patients with TC, TG, LDL-C index level declined obviously, HDL - C increased obviously; After treatment of carotid intima-media thickness （IMT）, plaque area and total scores were lower than before treatment, differences were statistically significant （P〈0.05）.Conclusion Carotid artery atherosclerosis in coronary heart disease in the clinical treatment of lipid adjusting treatment can improve the atherosclerotic plaques, is positive for the prognosis of patients with clinical significance.