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奥曲肽治疗恶性肠梗阻的疗效指数变化 被引量:1

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摘要 目的通过疗效指数变化研究奥曲肽联合胃肠减压治疗恶性肿瘤所致肠梗阻疗效。方法入组33例晚期恶性肿瘤患者,随机分为对照组、联合组,其中对照组采用胃肠减压为主治疗方案,联合组采用胃肠减压+醋酸奥曲肽静脉滴注,观察患者疗效指数变化。结果全组33例均可评价疗效,联合组与对照组之间在7、14 d后有效率存在统计学差异(P<0.05),但在4天后评价两组之间未见差异性(P>0.05),7、14 d后联合组之间也未显示出统计学差异(P>0.05)。结论胃肠减压早期联合奥曲肽治疗恶性肠梗阻疗效确切,临床可根据患者的病情需要采用不同奥曲肽使用方案。
作者 经萍 刘飞
出处 《中国医药指南》 2014年第28期122-123,共2页 Guide of China Medicine
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参考文献9

  • 1Klein C,Stiel S,Biikki J,et al.Pharmacological treatment of malignant bowel obstruction in severely ill and dying patients: a systematic literature review[J].Schmerz,2012,26(5):587-599.
  • 2Uchino R,Kusano S,Hanada N,et al.Clinical efficacy of octreotide acetate in cancer patients with malignant bowelsymptoms depend on terminal stage[J].Gan To Kagaku Ryoho,2011,38(2):255-257.
  • 3Davies DE,Wren T, MacLachlan SM.Octreotide infusion formalignant duodenal obstruction in a 12-year-old girl with metastatic peripheral nerve sheath mmor[J].J Pediatr Hematol Oncol,2012,34(7):e292-294.
  • 4Watari H, Hosaka M,Wakui Y, et al.A prospective study on the efficacy of oetreotide in the management of malignantbowel obstruction in gynecologic cancer[J]-Int J Gynecol Cancer,2012,22(4):692-696.
  • 5Mercadante S,Porzio G.Octreotide for malignant bowel obstruction twenty years after[J].Crit Rev Oncol Hematol,2012,83(3):388-392.
  • 6Laval G,Rousselot H,Toussaint-Martel S,et al.SALTO:a randomized,multicenter study assessing octreotide LAR in inoperable bowel obstruction[J].Bull Cancer,2012,99(2):E1-9.
  • 7Tanimura K,Onda S,Mitsunobu M.Effective made of octreotide intravenous administration for malignantgastrointestinal obstruction in terminal cancer patients[J].Gan To Kagaku Ryoho,2010,37(10):1991-1993.
  • 8俞谦,孙为豪,刘顺英,欧希龙,曹大中,苏菡,江洁,俞婷.奥曲肽联合特异性COX-2抑制剂对肝癌细胞的抑制作用[J].东南大学学报(医学版),2005,24(6):363-367. 被引量:4
  • 9李炜虹,沈杨,张云霞,任慕兰.奥曲肽抑制人卵巢癌细胞增殖的研究[J].东南大学学报(医学版),2010,29(4):427-429. 被引量:2

二级参考文献14

  • 1金正均.合并用药中的相加[J].中国药理学报,1980,1:70-73.
  • 2SAMUELS B L. Management of recurrent desmoid tumor after surgery and radiation: role of cytotoxic and non-cytotoxic therapies[J]. Surg Oneol, 1999,8: 191-196.
  • 3KAYE S B, EISENHAUER E A, HAMILTON T C, et al. New noncytotoxic approaches to ovarian cancer [ J ]. Ann Oncol, 1999, 10(Suppl) : 165-168.
  • 4SAMONAKIS D N, MOSCHANDREAS J, ARNAOUTIS T, et al.Treatment of hepatocellular carcinoma with long acting somatostatin analogues[J]. Oncol Rep,2002,9:903-907.
  • 5SANO H,KAWAHIT Y,WILD R L,et al. Expression of cyclooxy-genase-1 and -2 in human colorectal cancer[J]. Cancer Res, 1995, 55 (17) : 3785-3789.
  • 6TSUJII M, KAWANO S, DUBOIS R N. Cyclooxygenase-expression in human colon cancer cells increases metastatic potential[J]. Proc Nail Acad Sci USA, 1997,94(7) :3336-3340.
  • 7SHENG H, SHAO J, MORROW J D, et al. Modulation of apoptosis and bcl-2 expression by prostaglandin E2 [J]. Cancer Res, 1998,58 (2) : 362-366.
  • 8TODISCO A, SEVA C, TAKEUCHI Y, et al. Somatostatin inhibits AP-1 function via multiple protein phosphatases[ J ]. Am J Physiol, 1959.269: G160-G166.
  • 9DING M, DONG Z, CHEN F, et al. Asbestos induces activator protein-1 transactivation in transgenic mice[J]. Cancer Res, 1999, 59:1884-1889.
  • 10HUSSIN S S, SZABO I L,PAI R, et al. MAPK(ERK2) kinase: a key target for NSAIDs-induced inhibition of gastric cancer cell proliferation and growth[J]. Life Sci,2001,69:3045-3054.

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