附子与干姜、甘草配伍使用后乌头碱含量的变化研究

Clinical research on the change of aconitine in compatible application of Fuzi and Ganjiang, Fuzi and Gancao

目的:研究附子与干姜、甘草配伍使用后乌头碱含量的改变。方法:将附子分别和干姜、甘草配伍,利用高效液相色谱法(HPLC)对其配伍后乌头碱含量改变情况加以检测。结果:附子与干姜、附子与甘草中乌头碱含量及有毒生物总碱含量显著低于附子,且附子与甘草中乌头碱含量及有毒生物总碱含量显著低于附子与干姜。结论:附子在许多疾病治疗中有显著效果,在临床中使用时可根据实际需求将之和干姜、甘草等合理配伍,促使附子内乌头碱含量降低,有效降低毒性,从而为患者的安全用药提供有力保证。

Objective： To investigate the change of aconitine in compatible application of Fuzi and Ganjiang, Fuzi and Gancao. Methods： The contents of the aconitine were determined by HPLC. Results： The contents of the aconitine and total alkali in Fuzi and Ganjiang, Fuzi and Gancao were significantly lower than Fuzi. Conclusion： Fuzi was effective on many diseases, it could be applied with Ganjiang, Gancao and other herbal medicine to decrease the content of aconitine and toxicity effectively, and could provide a strong guarantee on safe medication.