丙基硫氧嘧啶联合中药治疗甲亢的疗效观察

Curative observation on the treatment of Hyperthyroidism by Propylthiouracil combined with Chinese medicine

目的：采用丙基硫氧嘧啶联合中药治疗甲状腺功能亢进，观察其临床疗效。方法：选取2012年6月-2013年12月在我院内分泌科住院采用丙基硫氧嘧啶联合中药治疗的甲状腺功能亢进的34例患者作为观察组，只采用丙基硫氧嘧啶治疗的甲状腺功能亢进的34例患者作为对照组，对两组病例的临床资料进行回顾性研究，对比分析两组的临床疗效。结果：经过两组不同的治疗后，在患者的总三碘甲状腺原氨酸（FT3）、总甲状腺素（FT4）、游离三碘甲状腺原氨酸（TT3）、游离甲状腺素（TT4）等四个指标方面，两组均比治疗前显著降低，并且观察组比对照组降低的更明显，两组比较差异具有统计学意义（P＜0.05）。观察组的临床总有效率为91.17%，对照组的临床总有效率为70.58%，观察组的临床疗效明显优于对照组，两组比较差异具有统计学意义（P＜0.05）。结论：应用丙基硫氧嘧啶联合中药治疗甲亢比单纯应用丙基硫氧嘧啶治疗甲亢的临床疗效更好，值得在临床上广泛推广应用。

Objective：To observe the clinical therapeutic effect of propylthiouracil combined with Chinese medicine on the treatment of hyperthyroidism. Methods：34 cases of inpatients with hyperthyroidism in the Department of endocrinology of our hospital from June, 2012 to December, 2013 treated by propylthiouracil combined with Chinese medicine were regarded as the observation group, while 34 cases with thyroid hyperfunction treated by propylthiouracil were regarded as the control group. The clinical data of two cases were retrospectively reviewed and the clinical efficacy was analyzed. Results：After two different groups after treatment, compared with the total triiodothyronine （FT3）, the total thyroxine （FT4 three）, free triiodothyronine （TT3）, free thyroxine （TT4） and other four indicators, the two groups were significantly decreased than before treatment, and the observation group was obviously lower than the control group with significant differences between the two groups （P＜0.05）. The clinical total effective rate of the observation group was 91.17%, while that of the clinical control group was 70.58%, the clinical efficacy was better than of the observation group with significant differences between the two groups （P＜0.05）. Conclusion：The clinical effect of propylthiouracil combined with Chinese medicine on hyperthyroidism is better than the simple application of propylthiouracil which is worthy of clinic application.