血清细胞因子及纤维化指标与慢性肾衰的关系

Correlation between chronic renal failure and serum cytokines,serum fibrosis markers

目的:分析血清细胞因子及血清纤维化指标与慢性肾衰的相关性。方法:选取慢性肾衰病例70例作为慢性肾衰组(CRF),同时间健康志愿者70例作为对照组,比较两组血清炎症因子白细胞介素-6(IL-6)、白细胞介素-18(IL-18)、白细胞介素-10(IL-10)、可溶性白细胞介素-2受体(sIL-2R)、肿瘤坏死因子-α(TNF-α);血清纤维化相关指标胶原蛋白Ⅰ(CollagenⅠ)、胶原蛋白Ⅲ(CollagenⅢ)、Ⅲ型前胶原(PC-Ⅲ)、血清层黏蛋白(LN)、透明质酸(HA)水平差异;分析这些指标与内生肌酐清除率的相关性。结果:CRF组血清IL-6、IL-18、IL-10、sIL-2R、TNF-α水平明显高于对照组,血清CollagenⅠ、CollagenⅢ、PC-Ⅲ、LN、HA水平明显高于对照组,差异具有统计学意义(P<0.05);不同Ccr水平CRF患者血清炎症因子和纤维化指标水平比较,差异具有统计学意义(P<0.05);血清IL-6、IL-18、IL-10、sIL-2R、TNF-α水平及CollagenⅠ、CollagenⅢ、PC-Ⅲ、LN、HA水平均与Ccr水平均呈正相关。结论:血清细胞因子及纤维化指标水平与慢性肾衰的发生发展密切相关。

Objective：To analyze correlation between chronic renal failure（CRF）and serum cytokines and serum fibrosis markers.Methods：70patients with CRF were selected as CRF group,and 70 healthy volunteers as control group.The indexes of serum cytokines levels and serum fibrosis markers levels including IL-6,IL-18,IL-10,sIL-2R,TNF-α,CollagenⅠ,CollagenⅢ,PC-Ⅲ,LN,HA were compared between CRF group and control group,and correlation of these indicators and endogenous creatinine clearance（Ccr）were analyzed.Results：Serum levels of IL-6,IL-18,IL-10,sIL-2Rand TNF-αof CRF group were higher than control group;and the serum levels of CollagenⅠ,CollagenⅢ,PC-Ⅲ,LN,HA were higher than control group too（Pall0.05）.There were significantly differences in serum levels of inflammatory cytokines and fibrosis index level in CRF patients with different Ccr levels,the serum levels of IL-6,IL-18,IL-10,sIL-2Rand TNF-αand CollagenⅠ,CollagenⅢ,PC-Ⅲ,LN,HA all showed a positive correlation with the level of Ccr.Conclusion：The serum levels of inflammatory cytokines and fibrosis markers are closely related to the occurrence and development of chronic renal failure.