卵巢癌患者卵巢血流参数及组织MiR、KLK的变化

Observation on the change of ovarian blood flow parameters and tissue MiR,KLK of patients with ovarian carcinoma

目的:观察及探讨卵巢癌患者卵巢血流参数及组织微小RNA(MiR)、组织激肽释放酶(KLK)的变化情况。方法:选取本院收治的66例卵巢癌患者为观察组,另以同期的66例卵巢良性肿瘤患者为对照组,然后将两组的卵巢血流参数及组织MiR、KLK表达情况进行比较,比较观察组中不同分期卵巢癌患者的上述检测项目。结果:观察组的卵巢血流收缩期峰值流速(PSV)高于对照组,阻力指数(RI)及搏动指数(PI)均低于对照组,组织MiR表达低于对照组,KLK则高于对照组,且观察组中不同分期卵巢癌者的上述检测结果之间比较,差异均具有统计学意义(P均<0.05)。结论:卵巢癌患者卵巢血流参数及组织MiR、KLK的变化较大,且上述指标对于卵巢癌分期也有较高的诊断价值。

Objective：To observe and investigate changes of ovarian blood flow parameters and tissue MiR,KLK of patients with ovarian carcinoma.Methods：A total of 66 patients with ovarian carcinoma treated in our hospital were selected as observation group,66 patients with benign ovarian tumor at the same time were enrolled as control group,then the ovarian blood flow parameters and tissue MiR,KLK expression of two groups were analyzed and compared,then those detection items of observation group with different stages of ovarian carcinoma were compared.Results：The ovarian blood flow PSV of observation group was higher than that of control group,RI and PI were lower than those of control group,tissue MiR expression were lower than those of control group,KLK were higher than those of control group,and those detection results of patients with different stages of ovarian carcinoma in the observation group were significantly different too（Pall〈0.05）.Conclusion：Change of ovarian blood flow parameters and MiR,KLK in tissues of patients with ovarian carcinoma are great indicating they can be used for judging stages of ovarian carcinoma.