血清孕酮、促绒毛膜性腺激素水平检测对先兆流产合并绒毛膜下血肿妊娠结局的预测价值

Predictive value of serum progesterone,HCG levels for detection of threatened abortion complicated with subchorionic hematoma

目的:探讨早孕期绒毛膜下血肿的血清孕酮、促绒毛膜性腺激素(HCG)水平以及对妊娠结局的影响。方法:选取本院妇产科经常规B超检查确诊并接受治疗的先兆流产合并绒毛膜下血肿病例110例作为为研究组,并根据超声提示血肿大小将研究组分为轻度组及重度组。选取同期确诊的单纯先兆流产者90例作为对照组。各组均测定其血清孕酮及HCG水平,并对其术后妊娠结局进行随访。结果:在安胎治疗前研究组的孕酮及HCG水平均低于对照组,差异具有统计学意义(P<0.05);与安胎治疗前相比,安胎治疗后的孕酮及HCG水平均明显升高,差异具有统计学意义(P<0.05);对照组继续妊娠率明显高于研究组,且轻度组继续妊娠率明显高于重度组,差异具有统计学意义(P<0.05)。结论:早孕期绒毛膜下血肿患者的血清孕酮及HCG水平较低,有良好的预测作用,且绒毛膜下血肿对妊娠结局有不良影响。

Objective：To study serum progesterone,HCG levels in patients with threatened abortion complicated with subchorionic hematoma and its influence on the pregnancy outcomes.Methods：A total of 110 cases of threatened abortion complicated with subchorionic hematoma that were confirmed by B ultra-sound were selected as study group,and then subdivided into mild and severe groups according to the hematoma size under B ultra-sound.90 other simple threatened abortion cases were selected as control group.Serum progesterone and HCG levels were detected in all cases and follow-up were conducted to observe pregnancy outcomes.Results：Before fetus protection treatment,progesterone and HCG levels of the treatment group was lower than that of the control group（P〈0.05）.And progesterone and HCG levels were significantly increased after fetus protection treatment（P〈0.05）.Pregnancy rate of the control group was significantly higher than that of the study group,and pregnancy of the mild group was higher than that of the severe group（P〈0.05）.Conclusion：Serum progesterone and HCG levels are lower in pregnant patients with hematoma,thus these levels show predictive value.Subchorionic hematoma has negative influence on pregnancy outcomes.