阴道乳酸杆菌、高危型HPV-DNA载量与宫颈病变的关系研究

Correlation of vaginal lactobacilli and high-risk HPV-DNA load with cervical lesions

目的：探讨阴道乳酸杆菌数量、高危型HPV-DNA载量与宫颈病变的关系。方法：选择经HC-Ⅱ法检测高危型人乳头瘤病毒（HR-HPV）阳性的30例宫颈慢性炎症、56例宫颈上皮内瘤样病变（CIN）及35例宫颈癌患者作为研究对象,比较不同宫颈病变患者间阴道乳酸杆菌数量及HR-HPVDNA载量的差异。结果：HR-HPV-DNA载量中高度比例在宫颈炎症、CINⅠ/Ⅱ、CINⅢ及鳞癌患者中分别为20.00%、50.00%、76.67%、94.29%,依次上升,差异有统计学意义（P〈0.05）;阴道乳酸杆菌数量（×10^8-9-×10^10-11/L）比例在宫颈炎症、CINⅠ/Ⅱ、CINⅢ及宫颈鳞癌患者中分别为86.67%、65.38%、36.67%、14.29%,依次下降,差异有统计学意义（P〈0.05）。结论：HR-HPV-DNA高载量及阴道乳酸杆菌数量的减少与宫颈病变进展的关系密切,可作为发生癌前病变和宫颈癌的重要信号。

Objective：To investigate the relationship between vaginal lactobacilli quantity and HR-HPV-DNA load with cervical lesions.Methods：A total of 30 patients with chronic cervix inflammation,56 patients with cervical intraepithelial neoplasia（CIN）and 35 patients with cervical cancer were selected in this study,and lactobacilli quantity and HR-HPV-DNA load were detected and compared.Results：The middle and high proportion of HR-HPV-DNA load in cervical inflammation,CINⅠ/Ⅱ,CIN Ⅲand cervical cancer were 20.00%,50.00%,76.67%,94.29%,the difference was of statistically significant（P 0.05）;The proportion of vaginal lactobacilli（×108-9~×101 0-1 1）in cervical inflammation,CINⅠ/Ⅱ,CINⅢ and cervical cancer was 65.38%,36.67%,14.29%,the difference was of statistically significant（P〈0.05）.Conclusions：High load HR-HPV-DNA and reduction vaginal lactobacilli quantity are closely with progression of cervical lesions,and it can be regarded as an important indicator of precancerous lesions and cervical cancer.