乙肝相关性肝癌根治性术后抗病毒治疗对于患者预后的影响

Effect of antiviral therapy on prognosis of patients with HBV-related hepatocellular carcinoma after radical therapy

目的：研究乙肝相关性肝癌根治性术后抗病毒治疗对于患者预后的影响。方法：选取2011年3月-2013年3月期间本院收治的58例乙肝相关性肝癌根治性术后患者作为研究资料,按照随机对照原则将入组患者分为研究组和对照组,研究组患者接受抗病毒治疗,对照组患者仅接受基础治疗,对照两组患者治疗4、12、24及48周的肝功能、生存率以及生活质量。结果：研究组24、48周生存率均显著高于对照组（P〈0.05）。两组治疗前肝功能指标及HBV DNA水平无统计学差异（P〉0.05）,两组治疗48周时肝功能指标均与治疗前存在明显差异（P〈0.05）,研究组治疗48周时HBV DNA显著低于治疗前（P〈0.05）,对照组无统计学差异（P〉0.05）。研究组治疗48周时肝功能指标及HBV DNA水平均显著低于对照组（P〈0.05）。两组治疗前GIQLI生活质量评分无显著差异（P〉0.05）,研究组治疗4、12、24及48周GIQLI生活质量评分均高于对照组（P〈0.05）。结论：抗病毒治疗可以改善乙肝相关性肝癌根治性术后患者的预后,提高生存率及生活质量。

Objective： To explore effect of antiviral therapy on prognosis of patients with HBV-related hepatocellular carcinoma after radical therapy. Methods.. A total of 58 cases with B-related liver cancer admitted from March 2011- March 2013 were selected. They were divided into two groups. Patients in study group were treated with antiretroviral treatment, patients in the control group received only basic treatment. Liver function, survival rate and quality of life were observed and compared 4, 12, 24 and 48 weeks after treatment. Results.. Survival rate of study group at 24 and 48 weeks was significantly higher（P〈0.05）. There was no significant difference in HBV DNA level and liver function indicators between two groups before treatment（P〉0.05）. 48 weeks after treatment, liver function was significant improved in two groups（P〈0.05）, HI3V DNA was significantly decreased in study group（P〈0.05）, while there was no significant change in control group（P〉0.05）. HBV DNA level and liver function indicators were significantly lower in study group 48 weeks after treatment（P〈0.05）. Before treatment there was no significant difference in GIQLI score between two groups（P〈0.05）. 4,12, 24 and 48 weeks after treatment, GIQLI score was significantly higher in study group （P〈0. 05）. Conclusion： Antiviral therapy can improve the prognosis of HBV-related liver cancer patients after radical surgery, it can improve survival rate and quality of life.