乳腺癌发病危险因素的Meta分析

Meta- analysis on the risk factors for the incidence of breast cancer

目的探讨中国女性良性乳腺疾病、乳腺癌家族史和月经生育因素与乳腺癌的发病风险之间的关系。方法检索中外数据库,按照一定的标准获得有关乳腺癌危险因素的病例对照研究资料并使用Review man 5.0软件进行Meta分析。结果共纳入文献14篇,累计乳腺癌病例5 282例,对照6 409例,与对照人群相比,病例组合并后的OR值(95%CI):良性乳腺疾病(benign breast disease,BBD)为2.24(1.23,4.09),乳腺癌家族史(family history of breast cancer,FHBC)为2.05(1.47,2.86),月经生育因素中绝经(menopause)为0.93(0.61,1.41),母乳喂养(breastfeeding)为0.76(0.62,0.92),流产(abortion)为1.47(1.04,2.07)。结论良性乳腺疾病、乳腺癌家族史及流产为中国女性乳腺癌发病的危险因素,母乳喂养为中国女性乳腺癌的保护因素,绝经与否与中国女性的乳腺癌发病没有显著性联系。

Objective To explore the association between the risk of breast cancer occurrence and benign breast disease （BBD）, family history of breast cancer （FHBC） of breast cancer, menstrual and reproductive factors, including menopause, breastfeeding and abortion among Chinese women by systematically reviewing the risk of the original studies. Methods A comprehensive search was conducted to identify all case - control studies of the risk factors of breast cancer. Meta - analysis was applied with Rev Man 5.0 mftware for calculation of pooled OR values （with 95 % （71） of these factors. Results Altogether 14 case- control studies, including 5,282 patients and 6,409 controls were enrolled in this research. Compared with the control group, the pooled odds ratios （with 95 % CI） of the five factors of breast cancer patients were 2.24 （ 1.23, 4.09） for BBD, 2.05 （1.47, 2.86） for （FHBC）, 0.93 （0.61, 1.41） for menopause, 0.76 （0.62, 0.92） for breastfeeding and 1.47 （1.04, 2.07） for abortion, respectively. Conclusions BBD, FHBC and abortion are the risk factors for breast cancer among Chinese women, while breastfeeding is a protective factor for breast cancer. There is no significant correlation between menopause and breast cancer occurrence among Chinese women.