丹红注射液对急性冠脉综合征C反应蛋白及脑钠肽影响被引量：1

Influence of Danhong Injection for High-Sensitivity C-Reactive Protein and Brain Natriuretic Peptide(BNP)Plasma of Patients with Acute Coronary Syndrome

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摘要目的:探讨急性冠脉综合征患者血浆中的高敏C-反应蛋白(hs-CRP)、脑钠肽(BNP)水平变化及其临床意义及丹红注射液对两者的影响。方法:(1)选取我院急性冠脉综合征患者126例,不稳定型心绞痛41例,非ST段抬高型心肌梗死组43例,ST段抬高型心肌梗死42例,健康体检者53例,测其hs-CRP及脑钠肽前体(NTproBNP)浓度。(2)将126例急性冠脉综合征分为治疗组75例,非治疗组47例,治疗组给予常规西药治疗基础上加用丹红注射液30 mL静滴。结果:(1)不稳定型心绞痛、非ST段抬高型心肌梗死及ST段抬高型心肌梗死之间hsCRP及NT-proBNP浓度依次递增,组间差异均有统计学意义(P<0.05)。(2)治疗组hs-CRP及NT-proBNP浓度明显低于非治疗组,两组之间有统计学差异(P<0.05)。结论:(1)血浆hs-CRP及NT-proBNP浓度检测可为急性冠脉综合征病情评估提供重要的参考价值。(2)丹红注射液能改善ACS患者病情程度,增加治疗效果。 Objective：To investigate the high-sensitivity C-reactive protein （hs-CRP）and brain natriuretic peptide （ BNP ） plasma of patients with acute coronary syndrome （ ACS ） and its clinical significance and Danhong Injection on both. Method ：（ 1 ）The hs-CRP and NT-proBNP concentrations were measured in 126 patients with acute coronary syndrome included 41 patients with unstable angina （ UA ）, 43 patients with non-ST segment elevation myocardial infarction （ NSTEMI ）, and 42 cases with ST-segment elevation myocardial infarction （ STEMI ） and 53 cases of healthy. （ 2 ） 126 patients with acute coronary syndrome were divided into treatment group 75 cases, 47 cases of non-treatment group. The treatment group used Danhong Injection 30 mL based on the conventional medicine. Results：（ 1 ）An increasing trend was found in hs-CRP and NT-proBNP concentrations with unstable angina, non-ST segment elevation between myocardial infarction and ST segment elevation myocardial infarction. The differences of trend were statistically significant between groups （ P〈0.05 ）. （ 2 ） The hs-CRP and NT-proBNP concentrations in treatment groups were significantly lower than those of non-treated group, and had significant difference （ P〈0.05 ） in the two groups. Conclusion ： The plasma hs-CRP and NT-proBNP concentration scan can provide an important reference value for acute coronary syndrome. Danhong Injection can improve the degree of illness in patients with ACS and increase therapeutic effect.

作者刘积伦何亚军高爱红李军朋

机构地区陕西省核工业

出处《辽宁中医药大学学报》 CAS 2014年第10期174-175,共2页 Journal of Liaoning University of Traditional Chinese Medicine

关键词急性冠脉综合征脑钠肽高敏C-反应蛋白丹红注射液 acute coronary syndrome brain natriuretic peptide high-sensitivity C-reactive protein Danhong Injection

分类号 R541 [医药卫生—心血管疾病]

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