加味四妙勇安汤治疗糖尿病足临床疗效观察

Clinical Observation of Treating Diabetic Foot with Simiao Yongan Decoction

目的:探讨加味四妙勇安汤治疗糖尿病足(diabetic foot,DF)的临床疗效。方法:将73例DF患者随机平均分为观察组和对照组。对照组按病情给予降糖及抗感染、营养神经、改善微循环治疗,治疗组在对照组治疗基础上加用中药四妙勇安汤加减治疗,临证时根据病情的变化进行加减,疗程4周。治疗前后检测患肢创面面积、足背动脉血流量、踝臂指数(ABI)、神经运动传导速度(MCV)和感觉传导速度(SCV)改善情况等进行比较。结果:治疗组总有效率(92.11%)明显优于对照组总有效率(77.14%),差异具有统计学意义(P<0.05);2组患者治疗4周后患足溃疡创面面积与本组治疗前比较差异有统计学意义(P<0.05);治疗组患者治疗4周后患足溃疡创面面积与对照组治疗后比较差异有统计学意义(P<0.05);2组患者治疗后足背动脉血流量、ABI、MCV及SCV与本组治疗后比较差异有统计学意义(P<0.05);治疗组患者治疗后足背动脉血流量、ABI、MCV及SCV与对照组治疗后比较差异有统计学意义(P<0.05)。结论:加味四妙勇安汤治疗DF可以明显提高治疗有效率,显著改善DF患者下肢血液供应,并提高MCV和SCV,促进病变神经功能的恢复。

Objective ： To observe the efficacy of treating diabetic foot with Simiao Yongan Decoction. Methods ： 75 cases of diabetic foot patients were randomly divided into two groups, the treatment group （ 38 cases ） and control group （ 35 cases ）. Besides the same basic treatment, the treatment group was given Simiao Yongan Decoction for treatment. The changes of ulcer healing rate, the average healing time, ankle- brachial index （ ABI ）, motor nerve conduction velocity （ MNCV ） and sensory nerve conduction velocity （SNCV） were observed. Results：The total effective rate was 92.11% in the treatment group, and in the control group, the total effective rate was 77.14%. The healing rate, ABI, MNCV and SNCV of treatment group had significant difference compared with those of control group （ P〈0.05 ） .Conclusion ： Treating diabetic foot with Simiao Yongan Decoction can significantly improve efficacy.