叶酸预防大肠腺瘤息肉复发作用的临床随访研究

Clinical Follow-up Study of Folic Acid on Prevention of the Recurrence of Colorectal Adenomatous Polyps

目的:对叶酸预防大肠腺瘤息肉复发的临床效果进行分析研究。方法:选取2007年2月-2012年2月笔者所在医院收治的180例大肠腺瘤性息肉患者,所有患者在内镜下行息肉电切除术,随机分为治疗组和对照组,每组90例,测定两组血清叶酸水平,按叶酸水平将治疗组和对照组各分为低叶酸水平组、高叶酸水平组,治疗组给予叶酸治疗,对照组不予以药物治疗,通过肠镜复查观察大肠息肉复发情况。结果:治疗组患者腺瘤复发率为25.6%,低于对照组的38.9%,治疗组高叶酸水平者复发率47.4%高于对照组的25.7%,但差异无统计学意义(P>0.05),治疗组低叶酸水平者复发率9.6%低于对照组的47.3%,差异有统计学意义(P<0.05)。结论:叶酸可有效降低低叶酸水平大肠腺瘤患者腺瘤复发率,具有积极的临床应用价值。

Objective：To analyze the clinical effect of folic acid on prevention of recurrence of colorectal adenomatous polyp.Method：180 cases of patients with colorectal adenomatous polyps from February 2007 to February 2012 in our hospital,all patients were treated with polyp resection by endoscopic,they were divided into the intervention group and the control group,90 cases in each group,the serum folate levels of two groups were determined,according to folate levels of the intervention group and the control group were divided into low folate levels group and high folate levels group,the intervention group was treated with folate,the control group was not treated with medication,the recurrence of colorectal adenomatous polyps were compared by colonoscopy review in two group.Result：The adenoma recurrence rate of the intervention group（25.6%） was lower than that of the control group（38.9%）.The adenoma recurrence rate of patients with high folate levels in the intervention group（47.4%） was higher than that of the control group（25.7%）,but the difference had no statistical significance（P〉0.05）.The adenoma recurrence rate of patients with low folate levels in the intervention group（9.6%） was lower than that of the control group（47.3%）,the difference was statistical significance（P〈0.05）.Conclusion：Folic can reduce the adenoma recurrence rate of patients with low folate levels,and has application value very positive.